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A toxic substance, responsible for the chills and high fever recurring every three to four days in malarial fever, is
- a)interferon
- b)haemozoin
- c)colostrum
- d)hirudin
Correct answer is option 'B'. Can you explain this answer?
Most Upvoted Answer
A toxic substance, responsible for the chills and high fever recurring...
In malaria, chills and shivers are caused by the release of toxic substance haemozoin into the blood at the time of RBCs rupture. It is generally followed by fever.
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A toxic substance, responsible for the chills and high fever recurring...
Toxic Substance in Malarial Fever
Malarial fever is primarily caused by the Plasmodium parasite, which infects red blood cells. The recurring chills and high fever experienced in malaria are closely linked to a toxic substance known as haemozoin.
What is Haemozoin?
- Haemozoin is a byproduct of the digestion of hemoglobin by the Plasmodium parasite.
- When the parasite invades red blood cells, it breaks down hemoglobin to obtain nutrients, leading to the production of haemozoin.
Role of Haemozoin in Symptoms
- Toxicity: Haemozoin is toxic to the human body. Its accumulation leads to an immune response that results in fever and chills.
- Immune Response: The body recognizes haemozoin as a foreign substance, triggering the release of pro-inflammatory cytokines. This response contributes to the hallmark symptoms of malaria.
Fever Cycle
- The fever in malaria typically occurs in cycles, every 48 to 72 hours, depending on the species of Plasmodium.
- Each cycle corresponds to the lifecycle of the parasite within red blood cells, leading to the release of more haemozoin and the subsequent immune response.
Conclusion
In summary, haemozoin is the toxic substance responsible for the recurring chills and high fever in malarial fever. Understanding its role helps in grasping the pathophysiology of malaria and the body's response to the infection.
Malarial fever is primarily caused by the Plasmodium parasite, which infects red blood cells. The recurring chills and high fever experienced in malaria are closely linked to a toxic substance known as haemozoin.
What is Haemozoin?
- Haemozoin is a byproduct of the digestion of hemoglobin by the Plasmodium parasite.
- When the parasite invades red blood cells, it breaks down hemoglobin to obtain nutrients, leading to the production of haemozoin.
Role of Haemozoin in Symptoms
- Toxicity: Haemozoin is toxic to the human body. Its accumulation leads to an immune response that results in fever and chills.
- Immune Response: The body recognizes haemozoin as a foreign substance, triggering the release of pro-inflammatory cytokines. This response contributes to the hallmark symptoms of malaria.
Fever Cycle
- The fever in malaria typically occurs in cycles, every 48 to 72 hours, depending on the species of Plasmodium.
- Each cycle corresponds to the lifecycle of the parasite within red blood cells, leading to the release of more haemozoin and the subsequent immune response.
Conclusion
In summary, haemozoin is the toxic substance responsible for the recurring chills and high fever in malarial fever. Understanding its role helps in grasping the pathophysiology of malaria and the body's response to the infection.
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A toxic substance, responsible for the chills and high fever recurring every three to four days in malarial fever, isa)interferonb)haemozoinc)colostrumd)hirudinCorrect answer is option 'B'. Can you explain this answer? for NEET 2025 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about A toxic substance, responsible for the chills and high fever recurring every three to four days in malarial fever, isa)interferonb)haemozoinc)colostrumd)hirudinCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for NEET 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for A toxic substance, responsible for the chills and high fever recurring every three to four days in malarial fever, isa)interferonb)haemozoinc)colostrumd)hirudinCorrect answer is option 'B'. Can you explain this answer?.
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