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With reference to Base Editing, consider the following statements:
1. Base Editing treatment is a modification of chimeric antigen receptor, or CAR, T-cell therapy.
2. It is a more precise gene-editing technique than CRISPR.
Which of the statements given above is/are correct?
- a)1 only
- b)2 only
- c)Both 1 and 2
- d)Neither 1 nor 2
Correct answer is option 'C'. Can you explain this answer?
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With reference toBase Editing, consider the following statements:1. Ba...
For the first time, a new gene editing technology called base editing was used to modify immune cells and successfully treat a teen with treatment-resistant leukemia.
About:
- Bases are the language of life.
- Just as letters in the alphabet spell out words that carry meaning, the billions of bases in one person’s DNA spell out the instruction manual for his/her body.
- Base Editing treatment is a modification of chimeric antigen receptor, or CAR, T-cell therapy.
- But instead of using the CRISPR gene editing technique to modify the patient’s immune cells, the clinicians used the more precise base editing technique to alter donor immune cells.
- With advances in genetic technology, scientists have been able to zoom into a precise part of the genetic code to alter the molecular structure of just one base, effectively changing its genetic instructions.
- Those edited cells are given to the patient to “rapidly find and destroy T-cells in the body, including leukemic T-cells.
- Base editing is an even more precise gene editing technique than CRISPR and has fewer risks of unwanted effects on the chromosomes and thus less risk of side effects.
T-cell acute lymphoblastic leukaemia (T-ALL):
- T-ALL affects the stem cells in the bone marrow that produce a particular kind of white blood cells (WBC) called T lymphocytes (T cells).
- These cells provide a person immunity by killing cells carrying infections, activating other immune cells, and regulating the immune response.
- At least 20% of these WBC are atypical– as they accumulate in the bone marrow, they crowd out “good” WBCs and hence weaken the immune system.
- These unhealthy cells can also accumulate in other parts of the body like the liver, spleen and lymph nodes.
- While found in both children and adults, T-ALL’s incidence decreases with age.
- Treatment:
- Typical treatment for T-ALL is similar to that of any leukaemia– chemotherapy and stem cell/bone marrow transplant.
Hence both statements are correct.
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With reference toBase Editing, consider the following statements:1. Base Editing treatment is a modification of chimeric antigen receptor, or CAR, T-cell therapy.2. It is a more precise gene-editing technique than CRISPR.Which of the statements given above is/are correct?a)1 onlyb)2 onlyc)Both 1 and 2d)Neither 1 nor 2Correct answer is option 'C'. Can you explain this answer?
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