With regard to insulin choose correct options.(a) C-peptide is not pre...
Insulin is a protein hormone that is composed of two chains, an A-chain having 21 amino acids and a B-chain having 30 amino acids, linked together by disulphide bonds (S-S). Insulin is derived from a 74-amino-acid prohormone molecule called proinsulin having C-peptide and this is removed before the processing of mature insulin and during the production of recombinant insulin, the two chains were separately produced and then linked with each other. C-peptide is absent in mature insulin.
With regard to insulin choose correct options.(a) C-peptide is not pre...
Insulin and C-peptide
Insulin is a hormone produced by the pancreas that plays a crucial role in regulating blood sugar levels. C-peptide is a short protein that is cleaved from pro-insulin to form mature insulin. Here are the correct options related to insulin and C-peptide:
C-peptide is not present in mature insulin
C-peptide is indeed present in pro-insulin, but it is cleaved off during the maturation process to form mature insulin. Therefore, mature insulin does not contain C-peptide.
The insulin produced by rDNA technology has C-peptide
Insulin produced through recombinant DNA technology does not contain C-peptide. This is because the process involves synthesizing only the A and B chains of insulin, excluding the C-peptide.
The pro-insulin has C-peptide
Pro-insulin, which is the precursor to mature insulin, contains C-peptide. It consists of three components: the A-chain, the B-chain, and the C-peptide. During maturation, pro-insulin is cleaved at specific sites to form mature insulin, releasing the C-peptide in the process.
A-peptide and B-peptide of insulin are interconnected by disulphide bridges
The A-chain and B-chain of insulin are connected by disulphide bridges, which help maintain the structural integrity of the hormone. These disulphide bonds are crucial for the biological activity of insulin.
Therefore, the correct options are (a), (c), and (d) only, as they accurately describe the relationship between insulin and C-peptide.