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Consider the following statements regarding Diverse Epigenetic Epidemiology Partnership initiative:
- It aims to research the genetics behind Non-Communicable Diseases.
- It will help in understanding the variation in DNA methylation observed in people.
Which of the statements given above is/are correct?
- a)1 only
- b)2 only
- c)Both 1 and 2
- d)Neither 1 nor 2
Correct answer is option 'C'. Can you explain this answer?
Verified Answer
Consider the following statements regarding Diverse Epigenetic Epidemi...
The CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, is set to be part of the Diverse Epigenetic Epidemiology Partnership (DEEP).
- It is a ground-breaking integrated genomics and epigenomics study to understand the genetics behind Non-Communicable Diseases (NCDs) in diverse populations, including South Asians.
- The project is to uncover the effects of genomic and environmental diversity in disease risk observed in people across the world, including those in Asia, Africa and North and South America.
- It is a five-year international project.
- Researchers will be studying individuals representing diverse genetic and environmental contexts and learn which DNA methylation patterns contribute to their disease risk in each context
- The study will develop software and infrastructure and conduct advanced statistical analyses to build new resources.
- These new resources will sit alongside international health and genetics databases to look at trends in variation in DNA methylation.
- Significance of this initiative
- This research will enable identification of disease-causing mechanisms that are common worldwide and those which are unique to particular groups or regions.
- It will help with answering questions such as whether medicines developed in one part of the world will be effective for all.
- Ultimately the DEEP study hopes to enable targeted interventions or treatments and reduce global health disparity and inequity.
Hence both statements are correct.
Most Upvoted Answer
Consider the following statements regarding Diverse Epigenetic Epidemi...
Explanation:
The correct answer is option C, i.e., both statements 1 and 2 are correct.
Statement 1: It aims to research the genetics behind Non-Communicable Diseases.
The Diverse Epigenetic Epidemiology Partnership (DEEP) initiative aims to research the genetics behind Non-Communicable Diseases (NCDs). NCDs are diseases that are not transmitted from one person to another and are typically caused by a combination of genetic, environmental, and lifestyle factors. Examples of NCDs include cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes.
The DEEP initiative focuses on studying the epigenetics of NCDs. Epigenetics refers to changes in gene expression that are not caused by alterations in the DNA sequence itself. It involves modifications to the DNA molecule or the proteins associated with it, which can affect gene activity and the functioning of cells.
Statement 2: It will help in understanding the variation in DNA methylation observed in people.
DNA methylation is one of the epigenetic modifications that can influence gene expression. It involves the addition of a methyl group to the DNA molecule, which can affect the accessibility of genes and their transcription. DNA methylation patterns can vary between individuals and can be influenced by genetic and environmental factors.
The DEEP initiative aims to understand the variation in DNA methylation observed in people. By studying large and diverse population samples, researchers can identify common patterns of DNA methylation associated with NCDs. This can help in identifying potential biomarkers for disease risk and understanding the underlying mechanisms involved in the development of NCDs.
The DEEP initiative combines large-scale population studies, high-throughput epigenomic profiling, and advanced statistical analyses to investigate the epigenetic basis of NCDs. It involves collaborations between researchers from different disciplines, including genetics, epidemiology, and bioinformatics.
By elucidating the epigenetic factors contributing to NCDs, the DEEP initiative aims to improve our understanding of disease mechanisms, identify potential targets for prevention and treatment, and ultimately reduce the burden of NCDs on individuals and society.
Therefore, both statements 1 and 2 are correct.
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Consider the following statements regarding Diverse Epigenetic Epidemiology Partnership initiative: It aims to research the genetics behind Non-Communicable Diseases. It will help in understanding the variation in DNA methylation observed in people.Which of the statements given above is/are correct?a)1 onlyb)2 onlyc)Both 1 and 2d)Neither 1 nor 2Correct answer is option 'C'. Can you explain this answer?
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