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Consider the following statements regarding Cholesterol:
  1. LDL (low-density lipoprotein) carries cholesterol from other parts of your body back to your liver.
  2. A high level of LDL (low-density lipoprotein) cholesterol can lead to coronary artery disease.
Which of the statements given above is/are correct?
  • a)
    1 only
  • b)
    2 only
  • c)
    Both 1 and 2
  • d)
    Neither 1 nor 2
Correct answer is option 'B'. Can you explain this answer?
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Most Upvoted Answer
Consider the following statements regarding Cholesterol: LDL (low-dens...
Statement 1: LDL (low-density lipoprotein) carries cholesterol from other parts of your body back to your liver.

Explanation:
- LDL (low-density lipoprotein) is often referred to as "bad cholesterol" because it carries cholesterol from the liver to the cells in your body.
- It transports cholesterol to various tissues and organs, including the arteries.
- Cholesterol is an essential component of cell membranes and is required for the production of certain hormones and vitamin D.
- However, when there is an excessive amount of LDL cholesterol in the bloodstream, it can lead to the buildup of plaque in the arteries, increasing the risk of cardiovascular diseases.

Statement 2: A high level of LDL (low-density lipoprotein) cholesterol can lead to coronary artery disease.

Explanation:
- When LDL cholesterol levels are high, it can lead to the accumulation of cholesterol in the walls of the arteries, forming plaque.
- Over time, this plaque can narrow the arteries, reducing blood flow to the heart muscle.
- If the plaque ruptures, it can cause a blood clot to form, completely blocking the artery and leading to a heart attack.
- Coronary artery disease is a condition characterized by the narrowing and hardening of the coronary arteries, which supply oxygen-rich blood to the heart muscle.
- High levels of LDL cholesterol are one of the major risk factors for developing coronary artery disease.

Conclusion:
Both statements are correct. LDL cholesterol carries cholesterol from other parts of the body back to the liver, and a high level of LDL cholesterol can lead to coronary artery disease. Therefore, the correct answer is option B.
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Community Answer
Consider the following statements regarding Cholesterol: LDL (low-dens...
A novel vaccine aimed at reducing "bad" cholesterol has been created.
What is cholesterol?
  • Cholesterol is a waxy, fat-like substance that's found in all the cells in your body.
  • Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. 
  • Your body needs some cholesterol to work properly.
  • What are LDL and HDL?
  • Cholesterol travels through the blood on proteins called “lipoproteins.”
  • Two types of lipoproteins carry cholesterol throughout the body: LDL (low-density lipoprotein) and HDL (high-density lipoprotein).
  • LDL and HDL have different purposes.
  • LDL cholesterol, sometimes called “bad” cholesterol, makes up most of your body’s cholesterol. A high LDL level leads to a buildup of cholesterol in your arteries.
  • HDL cholesterol sometimes called “good” cholesterol, because it carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body.
  • How can a high LDL level raise my risk of disease?
  • If you have a high LDL level, this means that you have too much LDL cholesterol in your blood.
  • This extra LDL, along with other substances, forms plaque. The plaque builds up in your arteries; this is a condition called atherosclerosis.
  • Coronary artery disease happens when plaque builds up is in the arteries of your heart. It causes the arteries to become hardened and narrowed, which slows down or blocks the blood flow to your heart. This can cause angina (chest pain) or, if the blood flow is completely blocked, a heart attack.
Hence only statement 2 is correct.
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For some time, scientists have believed that cholesterol plays a major role in heart disease because people with familial hypercholesterolemia, a genetic defect, have six to eight times the normal level of cholesterol in their blood and they invariably develop heart disease. Scientists also noticed that people with familial hypercholesterolemia appear to produce more LDL’s (low-density lipoproteins) than normal individuals. However, scientists wondered, could a genetic mutation that causes a slowdown in the removal of LDL’s from the blood also result in an increase in the synthesis of this cholesterol-carrying protein? Since scientists could not experiment on human body tissue, their knowledge of familial hypercholesterolemia was severely limited. However, a breakthrough came in the laboratories of Yoshio Watanabe of Kobe University in Japan in 1980. Watanabe noticed that a male rabbit in his colony had ten times the normal concentration of cholesterol in its blood. By appropriate breeding, Watanabe obtained a strain of rabbits that had very high cholesterol levels. These rabbits spontaneously developed heart disease. To his surprise, Watanabe further found that the rabbits, like humans with familial hypercholesterolemia, lacked LDL receptors. What scientists learned by studying the Watanabe rabbits is that the removal of the VLDL (very low-density lipoproteins) remnant requires the LDL receptor. Normally, the majority of the VLDL remnants go to the liver where they bind to LDL receptors and are degraded. In the Watanabe rabbit, due to a lack of LDL receptors on liver cells, the VLDL remnants remain in the blood and are eventually converted to LDL’s. The LDL receptors thus have a dual effect in controlling LDL levels. They are necessary to prevent over synthesis of LDL’s from VLDL remnants and they are necessary for the normal removal of LDL’s from the blood.Q. The passage supplies information to answer which of the following questions?

For some time, scientists have believed that cholesterol plays a major role in heart disease because people with familial hypercholesterolemia, a genetic defect, have six to eight times the normal level of cholesterol in their blood and they invariably develop heart disease. Scientists also noticed that people with familial hypercholesterolemia appear to produce more LDL’s (low-density lipoproteins) than normal individuals. However, scientists wondered, could a genetic mutation that causes a slowdown in the removal of LDL’s from the blood also result in an increase in the synthesis of this cholesterol-carrying protein? Since scientists could not experiment on human body tissue, their knowledge of familial hypercholesterolemia was severely limited. However, a breakthrough came in the laboratories of Yoshio Watanabe of Kobe University in Japan in 1980. Watanabe noticed that a male rabbit in his colony had ten times the normal concentration of cholesterol in its blood. By appropriate breeding, Watanabe obtained a strain of rabbits that had very high cholesterol levels. These rabbits spontaneously developed heart disease. To his surprise, Watanabe further found that the rabbits, like humans with familial hypercholesterolemia, lacked LDL receptors. What scientists learned by studying the Watanabe rabbits is that the removal of the VLDL (very low-density lipoproteins) remnant requires the LDL receptor. Normally, the majority of the VLDL remnants go to the liver where they bind to LDL receptors and are degraded. In the Watanabe rabbit, due to a lack of LDL receptors on liver cells, the VLDL remnants remain in the blood and are eventually converted to LDL’s. The LDL receptors thus have a dual effect in controlling LDL levels. They are necessary to prevent over synthesis of LDL’s from VLDL remnants and they are necessary for the normal removal of LDL’s from the blood.Q. The passage implies that Watanabe rabbits differ from normal rabbits in which of the following ways?

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Consider the following statements regarding Cholesterol: LDL (low-density lipoprotein) carries cholesterol from other parts of your body back to your liver. A high level of LDL (low-density lipoprotein) cholesterol can lead to coronary artery disease.Which of the statements given above is/are correct?a)1 onlyb)2 onlyc)Both 1 and 2d)Neither 1 nor 2Correct answer is option 'B'. Can you explain this answer?
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