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Consider the following statements regarding the Western Equine Encephalitis virus infection:
  1. It is transmitted to humans through mosquitoes.
  2. Its virus has a long single-stranded RNA genome.
Which of the statements given above is/are correct?
  • a)
    1 only
  • b)
    2 only
  • c)
    Both 1 and 2
  • d)
    Neither 1 nor 2
Correct answer is option 'C'. Can you explain this answer?
Most Upvoted Answer
Consider the following statements regarding the Western Equine Encepha...
Recently, the International Health Regulations National Focal Point (IHR NFP) in Argentina alerted the World Health Organization of a human case of Western Equine Encephalitis Virus (WEEV) infection. 
  • It is a mosquito-borne infection caused by the Western Equine Encephalitis Virus (WEEV), which belongs to the Togaviridae family of viruses.
  • The virus has an approximately 11.5 kilobases long single-stranded RNA genome.
  • It is a recombinant of the eastern equine encephalitis virus (EEEV) and a Sindbis-like virus.
  • Passerine birds are thought to be the reservoir and equine species as intermediate hosts.
  • The primary mode of transmission of the infection to humans is through mosquitoes which act as vectors for the virus.
  • Symptoms:
  • While most of the infections are asymptomatic, the infection may lead to severe consequences in rare cases.
  • An estimated 4-5% of cases may manifest as infection/inflammation of the brain, resulting in neurological symptoms and sequelae of disease.
  • Treatment: With no specific antiviral treatment, symptomatic care is crucial, especially for neurologic symptoms.
Hence both statements are correct.
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Community Answer
Consider the following statements regarding the Western Equine Encepha...
The correct answer is option 'C' - Both 1 and 2.

Explanation:

1. It is transmitted to humans through mosquitoes:
- Western Equine Encephalitis (WEE) is a viral infection that is primarily transmitted to humans through the bite of infected mosquitoes. Mosquitoes become infected with the virus when they feed on infected birds, which act as the natural reservoir for the virus. Mosquito species such as Culex tarsalis and Culex pipiens are known to transmit WEE to humans.
- When an infected mosquito bites a human, the virus is transmitted and can cause illness.

2. Its virus has a long single-stranded RNA genome:
- The Western Equine Encephalitis virus belongs to the family Togaviridae and the genus Alphavirus.
- Alphaviruses have a single-stranded RNA genome. This genome is encapsulated in a protein coat.
- The RNA genome of the virus is relatively long and contains all the necessary genetic information for the virus to replicate and produce viral proteins.

In conclusion, both statements are correct. Western Equine Encephalitis virus is transmitted to humans through mosquitoes, and its virus has a long single-stranded RNA genome.
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