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20. In Huntington's disease, the unaffected persons are homozygous for normal allele h. The following is erroneous because
(a) It shows both male and female affected by Huntingtons disease
(b) Either person 6 or 7 should have the disease, if individual 11 shows the disease.
(c) At least one of the 2 children (8, 9) should have the disease
(d) All of these?
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20. In Huntington's disease, the unaffected persons are homozygous for...
Understanding Huntington's Disease Inheritance
Huntington's disease is a genetic disorder caused by a mutation in the HTT gene, leading to neurodegeneration. The inheritance pattern is autosomal dominant, meaning that an affected individual has a 50% chance of passing the mutated allele to their offspring.
Key Points of Erroneous Representation
  • Both Male and Female Affected:
    - The diagram shows individuals of both genders affected by Huntington's disease, which is correct as the disorder affects both sexes equally. Hence, this point is not erroneous.
  • Implication of Individual 11:
    - If individual 11 is affected, at least one of their parents (either 6 or 7) must also be affected. Since Huntington's disease is dominant, an unaffected parent (homozygous for normal allele h) cannot pass the disease allele. Therefore, this point is erroneous.
  • Children of Affected Individual:
    - Individuals 8 and 9 are the children of an affected individual (11). Each child has a 50% chance of inheriting the disease. However, if both are unaffected, the representation may imply a discrepancy in the expected inheritance pattern, making this point also erroneous.


Conclusion
The erroneous nature of the representation primarily stems from the implications surrounding individuals 6, 7, and their offspring (8, 9). The correct understanding of the autosomal dominant inheritance pattern must be reflected accurately in any pedigree representation of Huntington's disease. Therefore, options (b) and (c) highlight critical misunderstandings in the inheritance pattern, confirming that "All of these" could be considered erroneous based on the details provided.
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20. In Huntington's disease, the unaffected persons are homozygous for normal allele h. The following is erroneous because(a) It shows both male and female affected by Huntingtons disease(b) Either person 6 or 7 should have the disease, if individual 11 shows the disease.(c) At least one of the 2 children (8, 9) should have the disease(d) All of these?
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20. In Huntington's disease, the unaffected persons are homozygous for normal allele h. The following is erroneous because(a) It shows both male and female affected by Huntingtons disease(b) Either person 6 or 7 should have the disease, if individual 11 shows the disease.(c) At least one of the 2 children (8, 9) should have the disease(d) All of these? for UPSC 2024 is part of UPSC preparation. The Question and answers have been prepared according to the UPSC exam syllabus. Information about 20. In Huntington's disease, the unaffected persons are homozygous for normal allele h. The following is erroneous because(a) It shows both male and female affected by Huntingtons disease(b) Either person 6 or 7 should have the disease, if individual 11 shows the disease.(c) At least one of the 2 children (8, 9) should have the disease(d) All of these? covers all topics & solutions for UPSC 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for 20. In Huntington's disease, the unaffected persons are homozygous for normal allele h. The following is erroneous because(a) It shows both male and female affected by Huntingtons disease(b) Either person 6 or 7 should have the disease, if individual 11 shows the disease.(c) At least one of the 2 children (8, 9) should have the disease(d) All of these?.
Solutions for 20. In Huntington's disease, the unaffected persons are homozygous for normal allele h. The following is erroneous because(a) It shows both male and female affected by Huntingtons disease(b) Either person 6 or 7 should have the disease, if individual 11 shows the disease.(c) At least one of the 2 children (8, 9) should have the disease(d) All of these? in English & in Hindi are available as part of our courses for UPSC. Download more important topics, notes, lectures and mock test series for UPSC Exam by signing up for free.
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