Which of the following is the primary mechanism by which HIV attacks t...
HIV specifically targets and infects helper T-lymphocytes (TH cells), which play a key role in the immune system's response. This leads to a weakened immune system, making the body more susceptible to infections.
Topic in NCERT: Hiv replication and impact on helper t-lymphocytes
Line in NCERT: "hiv enters into helper t-lymphocytes (t), replicates and produce progeny viruses. the progeny viruses released in the blood attack other helper t-lymphocytes."
Which of the following is the primary mechanism by which HIV attacks t...
Understanding HIV and Its Impact on the Immune System
HIV, or Human Immunodeficiency Virus, primarily attacks the immune system, specifically targeting helper T-lymphocytes (CD4+ T cells). Here’s a detailed breakdown of how this occurs:
Mechanism of Attack
- Infection of Helper T-Lymphocytes:
- HIV has a unique affinity for CD4+ T cells, which are crucial in orchestrating the immune response.
- The virus binds to the CD4 receptor and co-receptors (CCR5 or CXCR4) on the surface of these cells, facilitating its entry.
- Replication Inside the Cells:
- Once inside, HIV uses the host cell's machinery to replicate itself, leading to the production of new viral particles.
- This process ultimately results in the death of the infected T cells.
Consequences of CD4+ T Cell Depletion
- Impairment of Immune Response:
- As HIV continues to infect and destroy helper T cells, the immune system becomes increasingly compromised.
- Patients become more susceptible to opportunistic infections and certain cancers due to the lack of adequate immune response.
Other Options Explained
- Direct Attack on Red Blood Cells (Option A):
- HIV does not target red blood cells; its primary focus is on T-lymphocytes.
- Causing Mutations in DNA of Immune Cells (Option C):
- While HIV can integrate into the host DNA, its primary mechanism is not through causing mutations but rather through direct infection and destruction of T cells.
- Inhibiting Antibody Production (Option D):
- Although HIV indirectly affects antibody production by reducing T cell help, this is a secondary effect of T cell depletion.
In summary, the primary mechanism by which HIV attacks the immune system is through the infection and destruction of helper T-lymphocytes, leading to a compromised immune response.