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Which of the following reasons is mainly responsible for graft rejection in transplantation of organs? (NEET 2022 Phase 2)
- a)Cell-mediated response
- b)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cells
- c)Humoral immune response only
- d)Auto-immune response
Correct answer is option 'A'. Can you explain this answer?
Most Upvoted Answer
Which of the following reasons is mainly responsible for graft rejecti...
- Option (1) is the correct answer as the body is able to differentiate between ‘self’ and ‘non-self’ and the cell-mediated immune response is responsible for the graft rejection.
- Option (2) is incorrect as body of higher vertebrates have the ability to differentiate foreign organisms from self cells.
- Option (4) is incorrect as the autoimmune response occur when the body’s immune system fails to recognize ‘self’ from ‘non-self’ and starts destroying the body’s own cells.
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Which of the following reasons is mainly responsible for graft rejecti...
Understanding Graft Rejection in Organ Transplantation
Organ transplantation is a critical medical procedure, but it often faces challenges such as graft rejection. The primary reason for this rejection is the body's immune response.
Cell-Mediated Response
- The correct answer, option 'A', emphasizes the cell-mediated response as the main factor in graft rejection.
- This involves T lymphocytes (T cells) that identify foreign tissues. Intransplantation, the donor organ is recognized as "non-self" by the recipient's immune system.
Mechanism of Cell-Mediated Response
- T cells become activated upon recognizing foreign antigens on the transplanted cells.
- Once activated, these T cells proliferate and attack the graft, leading to inflammation and tissue damage.
- This process is crucial because it specifically targets and eliminates cells that do not match the recipient’s own tissue.
Why Other Options Are Less Relevant
- Option B: Inability to differentiate 'self' and 'non-self' - While this is a factor, the actual mechanism of rejection is driven by the immune response rather than a mere inability to differentiate.
- Option C: Humoral immune response only - This refers to antibody-mediated reactions, which can contribute to rejection, but the primary mechanism is still cell-mediated.
- Option D: Auto-immune response - Autoimmune responses involve the body attacking its own tissues, which is not the case in transplantation situations.
Conclusion
The cell-mediated response is a sophisticated and targeted mechanism by which the immune system protects the body from foreign invaders. Understanding this concept is crucial for improving graft survival rates in transplantation.
Organ transplantation is a critical medical procedure, but it often faces challenges such as graft rejection. The primary reason for this rejection is the body's immune response.
Cell-Mediated Response
- The correct answer, option 'A', emphasizes the cell-mediated response as the main factor in graft rejection.
- This involves T lymphocytes (T cells) that identify foreign tissues. Intransplantation, the donor organ is recognized as "non-self" by the recipient's immune system.
Mechanism of Cell-Mediated Response
- T cells become activated upon recognizing foreign antigens on the transplanted cells.
- Once activated, these T cells proliferate and attack the graft, leading to inflammation and tissue damage.
- This process is crucial because it specifically targets and eliminates cells that do not match the recipient’s own tissue.
Why Other Options Are Less Relevant
- Option B: Inability to differentiate 'self' and 'non-self' - While this is a factor, the actual mechanism of rejection is driven by the immune response rather than a mere inability to differentiate.
- Option C: Humoral immune response only - This refers to antibody-mediated reactions, which can contribute to rejection, but the primary mechanism is still cell-mediated.
- Option D: Auto-immune response - Autoimmune responses involve the body attacking its own tissues, which is not the case in transplantation situations.
Conclusion
The cell-mediated response is a sophisticated and targeted mechanism by which the immune system protects the body from foreign invaders. Understanding this concept is crucial for improving graft survival rates in transplantation.
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Question Description
Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer? for NEET 2025 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer? covers all topics & solutions for NEET 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer?.
Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer? for NEET 2025 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer? covers all topics & solutions for NEET 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer?.
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Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer?, a detailed solution for Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer? has been provided alongside types of Which of the following reasons is mainly responsible for graft rejection in transplantation of organs?(NEET 2022 Phase 2)a)Cell-mediated responseb)Inability of recipient to differentiate between ‘self’ and ‘non-self’ tissues/cellsc)Humoral immune response onlyd)Auto-immune response Correct answer is option 'A'. Can you explain this answer? theory, EduRev gives you an
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