Which one of the following is not applicable to RNA? [2015 RS]a...
Chargaff's rules are applicable only for double stranded DNA molecule. These are not applicable for single stranded DNA or RNA molecules. Chargaffs rules state that DNA helices contain equal molar ratios of A and T, G and C. This is because in a ds DNA molecule, complementary base pairing occurs between A and T, and C and G base pairs.
This complementary base pairing is not possible in case of single stranded RNA molecule. Thus, ChargafTs rules are not applicable to RNA.
Which one of the following is not applicable to RNA? [2015 RS]a...
RNA and its Properties
RNA is a nucleic acid that is found in both prokaryotes and eukaryotes. It is a single-stranded molecule that is made up of nucleotides, just like DNA. RNA has several properties that differentiate it from DNA, including:
Heterocyclic nitrogenous bases
RNA contains four nitrogenous bases: adenine (A), guanine (G), cytosine (C), and uracil (U). Uracil is a pyrimidine base that replaces thymine found in DNA.
5' phosphoryl and 3' hydroxyl ends
RNA has a 5' end with a phosphate group attached to the 5' carbon of the ribose sugar, and a 3' end with a hydroxyl group attached to the 3' carbon of the ribose sugar.
Complementary base pairing
Like DNA, RNA also follows the base pairing rules, where A pairs with U and C pairs with G.
Not applicable to RNA
Chargaff's rule, which states that the amount of adenine is equal to thymine and the amount of guanine is equal to cytosine, does not apply to RNA. This is because RNA contains uracil instead of thymine.
Conclusion
Therefore, the correct answer is option C, Chargaff's rule, as it is not applicable to RNA due to the presence of uracil instead of thymine.
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