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The genetic defect - Adenosine deaminase (ADA) deficiency may be cured permanently by:
[2009]
  • a)
    administering adenosine deaminase activators.
  • b)
    introducing bone marrow cells producing ADA into cells at early embryonic stages.
  • c)
    enzyme replacement therapy.
  • d)
    periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.
Correct answer is option 'B'. Can you explain this answer?
Verified Answer
The genetic defect - Adenosine deaminase (ADA) deficiency may be cured...
By introducing bone marrow cells producing ADA into cells at early embryonic stages, the genetic defect adenosine deaminase (ADA) deficiency may be cured permanently. It is due to mutation.
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The genetic defect - Adenosine deaminase (ADA) deficiency may be cured...
Introducing Bone Marrow Cells Producing ADA into Cells at Early Embryonic Stages
- This method involves introducing bone marrow cells that produce the deficient enzyme ADA into cells at early embryonic stages.
- By doing this, the genetic defect causing ADA deficiency can be permanently corrected in the individual.
- The introduced bone marrow cells will differentiate and generate functional ADA, thereby providing a long-term solution to the deficiency.
This approach is particularly effective because it targets the root cause of the genetic defect and ensures that the individual's body can produce the necessary enzyme on its own. By introducing corrected cells at an early embryonic stage, the genetic defect is corrected from the very beginning of development, leading to a permanent cure for ADA deficiency.
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The genetic defect - Adenosine deaminase (ADA) deficiency may be cured permanently by:[2009]a)administering adenosine deaminase activators.b)introducing bone marrow cells producing ADA into cells at early embryonic stages.c)enzyme replacement therapy.d)periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.Correct answer is option 'B'. Can you explain this answer?
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