Consider the following four statements (i-iv) regarding kidney transpl...
Tissue and blood group matching are essential before undertaking kidney transplant. Even if kidney transplant is proper, the recipient may need to take immuno suppresant all his/her life. The ability of body to differentiate self and nonself and the cell-mediated immune response is responsible for graft rejection.
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Consider the following four statements (i-iv) regarding kidney transpl...
Statement (i): Even if a kidney transplant is proper the recipient may need to take immune suppressants for a long time
This statement is correct. After a kidney transplant, the recipient's immune system recognizes the transplanted kidney as foreign and mounts an immune response to reject it. To prevent rejection, immune suppressant medications are usually prescribed to the recipient. These medications help to suppress the immune response and allow the transplanted kidney to function properly. The recipient may need to take these medications for a long time, often for the rest of their life, to ensure the success of the transplant.
Statement (ii): The cell-mediated immune response is responsible for graft rejection
This statement is correct. The cell-mediated immune response, involving T lymphocytes, plays a major role in the rejection of a transplanted kidney. T lymphocytes recognize foreign antigens present on the transplanted kidney and initiate an immune response to destroy it. This response involves the activation of cytotoxic T cells, which directly attack and kill the cells of the transplanted kidney. The cell-mediated immune response is one of the main mechanisms through which the body rejects the graft.
Statement (iii): The B lymphocytes are responsible for rejection of the graft
This statement is incorrect. B lymphocytes are not primarily responsible for the rejection of a transplanted kidney. Unlike the cell-mediated immune response mediated by T lymphocytes, B lymphocytes are involved in the humoral immune response, which primarily produces antibodies. While antibodies can contribute to graft rejection by activating complement cascade and causing tissue damage, the cell-mediated immune response is considered the main mechanism responsible for graft rejection.
Statement (iv): The acceptance or rejection of a kidney transplant depends on specific interferons
This statement is incorrect. Interferons are signaling proteins that are produced and released by cells in response to viral infections or other immune triggers. They play a role in regulating the immune response and have antiviral properties. However, the acceptance or rejection of a kidney transplant is not primarily dependent on specific interferons. It is predominantly determined by the interaction between the recipient's immune system and the transplanted kidney, particularly the cell-mediated immune response.
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