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Which of the following combination of drugs has a dramatic rapid increase in sedative effect?
- a)Alcohol + Antihistamines
- b)Alcohol + Benzodiazepines
- c)Alcohol + Aspirin
- d)Amphetamine + Insulin
Correct answer is option 'B'. Can you explain this answer?
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Which of the following combination of drugs has a dramatic rapid incre...
This combination show effect on CNS and reduces brain activity. Doctor prescribed in sleeping disorders and anxiety. It has many side effects also.
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Which of the following combination of drugs has a dramatic rapid incre...
Understanding Drug Interactions
Drug interactions can significantly amplify the effects of certain substances. Among the combinations listed, alcohol paired with benzodiazepines presents a particularly dangerous scenario.
Alcohol + Benzodiazepines
- Mechanism of Action: Both alcohol and benzodiazepines are central nervous system (CNS) depressants. They enhance the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity, leading to sedation and relaxation.
- Synergistic Effect: When these substances are combined, their sedative effects do not simply add together; they can multiply. This synergistic interaction can lead to profound sedation, respiratory depression, and an increased risk of overdose.
- Clinical Risks: The rapid onset of increased sedation can impair motor function and cognitive abilities, leading to dangerous situations such as accidents or fatalities. This makes the combination particularly hazardous.
Comparison with Other Options
- Alcohol + Antihistamines: While this combination can also cause sedation, the effects are not as pronounced as with benzodiazepines.
- Alcohol + Aspirin: Aspirin does not have sedative properties, and thus does not significantly enhance the effects of alcohol.
- Amphetamines + Insulin: This combination does not produce a sedative effect; instead, it can lead to metabolic disturbances and is unrelated to sedation.
Conclusion
The combination of alcohol and benzodiazepines presents a dramatic and rapid increase in sedative effects due to their shared mechanism of action as CNS depressants, making it the most dangerous option among the choices provided.
Drug interactions can significantly amplify the effects of certain substances. Among the combinations listed, alcohol paired with benzodiazepines presents a particularly dangerous scenario.
Alcohol + Benzodiazepines
- Mechanism of Action: Both alcohol and benzodiazepines are central nervous system (CNS) depressants. They enhance the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity, leading to sedation and relaxation.
- Synergistic Effect: When these substances are combined, their sedative effects do not simply add together; they can multiply. This synergistic interaction can lead to profound sedation, respiratory depression, and an increased risk of overdose.
- Clinical Risks: The rapid onset of increased sedation can impair motor function and cognitive abilities, leading to dangerous situations such as accidents or fatalities. This makes the combination particularly hazardous.
Comparison with Other Options
- Alcohol + Antihistamines: While this combination can also cause sedation, the effects are not as pronounced as with benzodiazepines.
- Alcohol + Aspirin: Aspirin does not have sedative properties, and thus does not significantly enhance the effects of alcohol.
- Amphetamines + Insulin: This combination does not produce a sedative effect; instead, it can lead to metabolic disturbances and is unrelated to sedation.
Conclusion
The combination of alcohol and benzodiazepines presents a dramatic and rapid increase in sedative effects due to their shared mechanism of action as CNS depressants, making it the most dangerous option among the choices provided.
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Which of the following combination of drugs has a dramatic rapid increase in sedative effect?a)Alcohol + Antihistaminesb)Alcohol + Benzodiazepinesc)Alcohol + Aspirind)Amphetamine + InsulinCorrect answer is option 'B'. Can you explain this answer?
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