What will happen if the secretion of parietal cells of gastric glands is blocked with an inhibitor ?a)In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsinb)Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsinc)Gastric juice will be deficient in chymosind)Gastric juice will be deficient in pepsinogenCorrect answer is option 'A'. Can you explain this answer?

Question

Answer

Parietal or Oxyntic cells which secrete HCl and intrinsic factor(factor essential for absorption of vitamin B12).Proenzyme pepsinogen isconverted to active pepsin only by the exposure to HCl.so ans is option A

Answer

Parietal cells / Oxantic cells secrets HCl and intrinsic factor of which HCl is primerly involved in the activetion of the inactive pro enzyme pepsinogen which is secreted by cheaf cells of gastric gland .

Answer

Impact of blocking the secretion of parietal cells of gastric glands with an inhibitor:

Blocking the secretion of parietal cells of gastric glands with an inhibitor can have several consequences on the digestion process. The secretion of parietal cells plays a crucial role in the production of gastric juice, which contains hydrochloric acid (HCl) and various enzymes that aid in digestion.

1. Inactive pepsinogen:
- Parietal cells secrete HCl, which creates an acidic environment in the stomach.
- The acidic environment is essential for the activation of pepsinogen, an inactive enzyme produced by chief cells.
- In the absence of HCl secretion due to the inhibition of parietal cell secretion, inactive pepsinogen is not converted into the active enzyme pepsin.
- Pepsin is responsible for the breakdown of proteins into smaller peptides, and its absence can lead to inefficient protein digestion.

2. Enterokinase and trypsinogen:
- Enterokinase, an enzyme, is released from the duodenal mucosa in response to the presence of acidic gastric juice.
- Enterokinase converts trypsinogen, an inactive enzyme produced by the pancreas, into its active form called trypsin.
- Trypsin is necessary for the digestion of proteins in the small intestine.
- If parietal cell secretion is blocked, the release of enterokinase will be impaired, leading to the incomplete conversion of trypsinogen to trypsin.
- This can result in insufficient protein digestion in the small intestine.

3. Chymosin deficiency:
- Chymosin, also known as rennin, is an enzyme produced by the gastric glands in infants and young children.
- It is involved in the digestion of milk proteins, particularly casein.
- Blocking the secretion of parietal cells may lead to a deficiency of chymosin in the gastric juice, which can impair the digestion of milk proteins.

Conclusion:
The inhibition of parietal cell secretion of gastric glands can have significant consequences on the digestion process. It can lead to the deficiency of active pepsin, trypsin, and chymosin, resulting in inefficient protein digestion and impaired breakdown of milk proteins. Therefore, the correct answer is option A, where the absence of HCl secretion prevents the conversion of inactive pepsinogen into the active enzyme pepsin.

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