The muscles fatigue occurs due to accumulation of ??? (a) pyruvic acid (b) ATP (c) lactic acid (d) Eroman CO2?

Question

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Muscle fatigue occurs due to accumulation of Lactic acid...option C is the answer

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Answer (c) Lactic acid

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The muscles fatigue occurs due to accumulation of lactic acid by the process called anerobic respiration
lactic acid accumulates in the muscles when the muscles undergo vigorous exercises

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The answer is lactic acid because it is a substance which will accumulate in the muscles when you do lot of physical work and it causes fatigueness so option is c

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Due to the accumulation of lactic acid .It is accumulated due to anaerobic respiration

Answer

Introduction:
Muscle fatigue refers to the decline in muscle performance or the inability to maintain force output during repeated contractions. It occurs due to various factors, including the accumulation of certain substances within the muscle fibers. One of the most significant contributors to muscle fatigue is the accumulation of lactic acid.

Explanation:
Here's a detailed explanation of why the accumulation of lactic acid causes muscle fatigue:

1. Anaerobic Metabolism:
During intense exercise or when oxygen supply is limited, muscles rely on anaerobic metabolism to produce energy. In this process, glucose is broken down into pyruvic acid through a series of biochemical reactions in the cytoplasm of muscle cells.

2. Lactic Acid Formation:
Under anaerobic conditions, pyruvic acid is converted into lactic acid by an enzyme called lactate dehydrogenase. This conversion allows the regeneration of NAD+ (nicotinamide adenine dinucleotide), which is necessary for the continuation of glycolysis (breakdown of glucose).

3. Accumulation of Lactic Acid:
During intense exercise, the rate of lactic acid production exceeds its removal rate, leading to its accumulation in the muscle fibers. This buildup of lactic acid lowers the pH within the muscle cells, resulting in a condition called acidosis.

4. Effects on Muscle Function:
The accumulation of lactic acid has several detrimental effects on muscle function, leading to fatigue:
- Inhibition of Enzymes: Lactic acid inhibits key enzymes involved in muscle contraction, such as myosin ATPase, impairing the ability of muscle fibers to generate force.
- Interference with Calcium Release: Lactic acid interferes with the release of calcium ions from the sarcoplasmic reticulum, reducing the availability of calcium for muscle contraction.
- Disruption of Ion Balance: The increase in acidity disrupts the balance of ions (such as potassium and calcium) across the muscle cell membrane, affecting the excitability and contractility of the muscle fibers.

5. Other Factors:
While lactic acid accumulation is a major contributor to muscle fatigue, it is not the sole factor. Other factors such as depletion of ATP (adenosine triphosphate), accumulation of inorganic phosphate (Pi), and the production of free radicals also contribute to muscle fatigue.

Conclusion:
Muscle fatigue occurs due to the accumulation of lactic acid, among other factors. The buildup of lactic acid impairs muscle function by inhibiting enzymes, disrupting ion balance, and interfering with calcium release. Understanding the mechanisms of muscle fatigue is crucial for athletes and individuals involved in physical activities to optimize their performance and recovery.

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