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First reduction in pentose phosphate pathway is
- a)Oxidation of 6-phosphogluconate
- b)Oxidation of fructose 6-phosphate
- c)Oxidation of glucose 6-phosphate
- d)Oxidation of fructcose 5-phosphate
Correct answer is option 'C'. Can you explain this answer?
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First reduction in pentose phosphate pathway isa)Oxidation of 6-phosph...
PPP on the pentose phosphate pathway is an alternative pathway for the breakdown of glucose and is independent of glycolysis and Krebs cycle. This is the only process that helps in the formation of NADP. In this, 36 molecules of ATP are synthesized. This process starts with the first reduction of glucose 6 phosphates to 6-phosphogluconic acid.
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First reduction in pentose phosphate pathway isa)Oxidation of 6-phosph...
A group of structurally similar or dissimilar cells that perform a common function and have a common origin is called a tissue. A plant is made up of different kinds of tissues. The complex tissues are, however, composed of different kinds of cells and they perform different types of functions
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First reduction in pentose phosphate pathway isa)Oxidation of 6-phosph...
Explanation:
The pentose phosphate pathway (PPP), also known as the hexose monophosphate (HMP) shunt, is a metabolic pathway that generates NADPH and pentoses (5-carbon sugars) as intermediates. It is an alternative pathway to glycolysis for the metabolism of glucose.
Reduction in the Pentose Phosphate Pathway:
The reduction reactions in the pentose phosphate pathway involve the conversion of NADP+ (nicotinamide adenine dinucleotide phosphate) to NADPH (reduced form) and the production of pentose sugars.
Oxidation of Glucose 6-Phosphate:
The first reduction step in the pentose phosphate pathway occurs during the oxidation of glucose 6-phosphate. Glucose 6-phosphate is converted to 6-phosphogluconolactone by the enzyme glucose 6-phosphate dehydrogenase. This reaction generates NADPH as a byproduct.
Importance of NADPH:
NADPH is a crucial molecule in various biochemical reactions. It acts as a reducing agent, providing reducing equivalents for biosynthetic reactions, detoxification of reactive oxygen species (ROS), and maintenance of cellular redox balance. NADPH is required for the synthesis of fatty acids, cholesterol, and nucleotides.
Other Steps in the Pentose Phosphate Pathway:
After the oxidation of glucose 6-phosphate, the 6-phosphogluconolactone is hydrolyzed by the enzyme 6-phosphogluconolactonase to form 6-phosphogluconate. This reaction does not involve any reduction or oxidation.
Conclusion:
The first reduction step in the pentose phosphate pathway occurs during the oxidation of glucose 6-phosphate, which generates NADPH. Therefore, the correct answer is option C, oxidation of glucose 6-phosphate.
The pentose phosphate pathway (PPP), also known as the hexose monophosphate (HMP) shunt, is a metabolic pathway that generates NADPH and pentoses (5-carbon sugars) as intermediates. It is an alternative pathway to glycolysis for the metabolism of glucose.
Reduction in the Pentose Phosphate Pathway:
The reduction reactions in the pentose phosphate pathway involve the conversion of NADP+ (nicotinamide adenine dinucleotide phosphate) to NADPH (reduced form) and the production of pentose sugars.
Oxidation of Glucose 6-Phosphate:
The first reduction step in the pentose phosphate pathway occurs during the oxidation of glucose 6-phosphate. Glucose 6-phosphate is converted to 6-phosphogluconolactone by the enzyme glucose 6-phosphate dehydrogenase. This reaction generates NADPH as a byproduct.
Importance of NADPH:
NADPH is a crucial molecule in various biochemical reactions. It acts as a reducing agent, providing reducing equivalents for biosynthetic reactions, detoxification of reactive oxygen species (ROS), and maintenance of cellular redox balance. NADPH is required for the synthesis of fatty acids, cholesterol, and nucleotides.
Other Steps in the Pentose Phosphate Pathway:
After the oxidation of glucose 6-phosphate, the 6-phosphogluconolactone is hydrolyzed by the enzyme 6-phosphogluconolactonase to form 6-phosphogluconate. This reaction does not involve any reduction or oxidation.
Conclusion:
The first reduction step in the pentose phosphate pathway occurs during the oxidation of glucose 6-phosphate, which generates NADPH. Therefore, the correct answer is option C, oxidation of glucose 6-phosphate.
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First reduction in pentose phosphate pathway isa)Oxidation of 6-phosphogluconateb)Oxidation of fructose 6-phosphatec)Oxidation of glucose 6-phosphated)Oxidation of fructcose 5-phosphateCorrect answer is option 'C'. Can you explain this answer?
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