The correct statement among the given options is D) All of these.

Explanation:

Manipulation of Microbes, Plants, and Animals and Ethical Issues:
- The current interest in the manipulation of microbes, plants, and animals refers to the field of genetic engineering, which involves altering the genetic material of organisms.
- Genetic engineering has raised serious ethical issues due to the potential consequences of manipulating the genetic code of living organisms.
- Ethical concerns include the potential for unintended consequences, such as creating organisms with unpredictable traits or introducing harmful genetic modifications into the environment.
- Additionally, there are concerns about the moral implications of playing "god" by altering the fundamental nature of living organisms.

Possible Risk of Genetic Engineering: Accidental Production of Antibiotic Resistant Organisms:
- Genetic engineering does pose the risk of accidental production of antibiotic-resistant organisms.
- Antibiotic resistance occurs when bacteria or other microorganisms develop the ability to withstand the effects of antibiotics, rendering them ineffective.
- Genetic engineering techniques can inadvertently transfer antibiotic resistance genes between organisms, leading to the creation of antibiotic-resistant strains.
- This can have serious implications for human health, as it may result in the emergence of untreatable infections.

Contribution of Genetic Engineering to Human Welfare:
- Despite the risks and ethical concerns, genetic engineering offers significant contributions to human welfare.
- It has the potential to revolutionize fields such as medicine, agriculture, and environmental conservation.
- Genetic engineering allows for the development of genetically modified crops with enhanced nutritional content, increased resistance to pests and diseases, and improved yield.
- In medicine, it enables the production of pharmaceuticals using genetically modified organisms, offering more effective and targeted treatments.
- Genetic engineering also plays a crucial role in research, allowing scientists to study and understand the genetic basis of diseases and develop potential therapies.

Conclusion:
All of the given statements are correct. The current interest in the manipulation of microbes, plants, and animals has raised serious ethical issues. There is a possible risk of genetic engineering, such as the accidental production of antibiotic-resistant organisms. However, genetic engineering offers significant contributions to human welfare, outweighing the potential threats. It has the potential to improve agriculture, medicine, and environmental conservation, among other fields.