Read the given statements and select the correct option.Statement 1 : ...
About 20−25% of CO2 is carried by Hb as carbamino-haemoglobin. CO2 reacts directly with amine radicals (NH2) of Hb of form an unstable compound called carbaminohaemoglobin which releases CO2 in the lungs.
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Read the given statements and select the correct option.Statement 1 : ...
Statement 1: About 70% of CO2 that enters RBCs changes into HCO3- for transport in plasma to the lungs where it reconverts into CO2 for elimination.
Statement 2: About 40% of CO2 that enters RBCs changes into carbaminohaemoglobin which releases O2 in the lungs.
Explanation:
Transport of Carbon Dioxide (CO2) in the blood involves several mechanisms. Let's discuss each statement separately:
Statement 1:
About 70% of CO2 that enters RBCs changes into HCO3- for transport in plasma to the lungs where it reconverts into CO2 for elimination.
- When CO2 enters the RBCs, it combines with water (H2O) to form carbonic acid (H2CO3) through the action of an enzyme called carbonic anhydrase.
- Carbonic acid (H2CO3) dissociates into bicarbonate ions (HCO3-) and hydrogen ions (H+).
- The bicarbonate ions (HCO3-) are transported out of the RBCs and into the plasma, where they are carried to the lungs.
- In the lungs, the reverse process occurs. Bicarbonate ions (HCO3-) re-enter the RBCs and combine with hydrogen ions (H+) to form carbonic acid (H2CO3).
- Carbonic acid (H2CO3) then breaks down into CO2 and water (H2O) through the action of carbonic anhydrase.
- The CO2 produced is then eliminated from the body through exhalation.
Statement 2:
About 40% of CO2 that enters RBCs changes into carbaminohaemoglobin which releases O2 in the lungs.
- Apart from being converted into bicarbonate ions, a small portion of CO2 that enters RBCs combines directly with hemoglobin to form carbaminohaemoglobin.
- This process occurs in the tissues where oxygen (O2) is released from hemoglobin to the tissues.
- In the lungs, when blood reaches the alveoli, the high concentration of oxygen causes the release of carbon dioxide from carbaminohaemoglobin.
- The released CO2 then follows the process mentioned in Statement 1 to be eliminated from the body.
Explanation of the correct option:
The correct option is 'C' - Statement 1 is correct and statement 2 is incorrect.
Statement 1 correctly explains the process of CO2 transport through bicarbonate ions in RBCs and plasma to the lungs. However, Statement 2 is incorrect as only a small portion (about 20-25%) of CO2 combines with hemoglobin to form carbaminohaemoglobin, not 40%. Additionally, the release of oxygen from hemoglobin in the lungs is not directly related to the formation of carbaminohaemoglobin.
Hence, option 'C' is the correct answer.
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