A patient of diabetes mellitus excretes glucose in urine even when he ...
In diabetes mellitus, a patient is unable to produce or utilise insulin hormone. This hormone helps in maintaining the level of glucose in the blood by converting extra glucose into glycogen. Thus, in diabetes mellitus, the body of the patient becomes incapable to store glucose in the form of glycogen. Therefore, he starts excreting glucose in the urine. If a patient kept on a carbohydrate-free diet is excreting glucose in the urine, then this means, high level of glucose in the blood not only depends on dietary carbohydrates but also on glycogenolysis (breakdown of glycogen into glucose in the liver) and gluconeogenesis(breakdown of fats into glucose in adipose tissues).
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A patient of diabetes mellitus excretes glucose in urine even when he ...
Explanation:
When a patient with diabetes mellitus excretes glucose in urine even when kept on a carbohydrate-free diet, it indicates that the body is unable to regulate blood glucose levels properly. This is due to the absence or insufficient production of insulin, a hormone that helps regulate glucose metabolism.
Reasons behind glucose excretion in urine:
There are several reasons why a patient with diabetes mellitus may excrete glucose in urine despite being on a carbohydrate-free diet. These reasons include:
1. Glucose production from fats: In the absence of carbohydrates, the body can still produce glucose through a process called gluconeogenesis. This process involves the breakdown of fats (lipids) stored in adipose tissues to form glucose. This newly formed glucose can then enter the bloodstream and be excreted in urine.
2. Insufficient suppression of gluconeogenesis: In individuals with diabetes, the normal regulation of gluconeogenesis may be impaired. Even in the absence of dietary carbohydrates, the liver continues to produce glucose through gluconeogenesis. This excess glucose can exceed the reabsorptive capacity of the kidneys, leading to its excretion in urine.
3. Impaired glucose reabsorption: Normally, the kidneys reabsorb glucose from the urine back into the bloodstream. However, in patients with diabetes mellitus, the elevated blood glucose levels can exceed the renal threshold for glucose reabsorption. As a result, glucose is not adequately reabsorbed, leading to its excretion in urine.
4. Other metabolic abnormalities: Diabetes mellitus can also lead to other metabolic abnormalities, such as increased breakdown of muscle glycogen and increased release of amino acids from muscle tissue. These amino acids can be converted into glucose through gluconeogenesis in the liver, further contributing to the presence of glucose in the urine.
Summary:
In summary, a patient with diabetes mellitus may excrete glucose in urine even when kept on a carbohydrate-free diet due to the production of glucose from fats, insufficient suppression of gluconeogenesis, impaired glucose reabsorption by the kidneys, and other metabolic abnormalities associated with diabetes. These factors contribute to the elevated blood glucose levels and subsequent excretion of glucose in urine.
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