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Which of the following immune responses is responsible for rejection of kidney graft?
- a)Auto-immune response
- b)Humoral immune response
- c)Inflammatory immune response
- d)Cell-mediated immune response
Correct answer is option 'D'. Can you explain this answer?
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Which of the following immune responses is responsible for rejection o...
The body is able to differentiate self and nonself and the cell-mediated response is responsible for graft rejection.
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Which of the following immune responses is responsible for rejection o...
Cell-mediated immune response
The rejection of a kidney graft is primarily mediated by the cell-mediated immune response. This involves the activation of T cells, particularly cytotoxic T cells, which recognize the transplanted kidney as foreign tissue.
Mechanism
- Upon transplantation, the donor kidney's antigens are recognized by the recipient's T cells as non-self.
- Cytotoxic T cells are activated and target the donor kidney cells for destruction.
- This leads to inflammation and tissue damage in the transplanted kidney, ultimately causing rejection.
Role of T cells
- CD8+ cytotoxic T cells directly attack and destroy the donor kidney cells.
- CD4+ T helper cells play a role in activating other immune cells and promoting the immune response against the graft.
Prevention and treatment
- To prevent rejection, patients undergoing kidney transplantation are often prescribed immunosuppressive medications to suppress the immune response.
- In cases of acute rejection, additional immunosuppressive therapy may be required to control the immune response and salvage the graft.
In summary, the cell-mediated immune response plays a crucial role in the rejection of kidney grafts by targeting the transplanted organ as foreign tissue. Understanding and managing this immune response is essential in the success of kidney transplantation.
The rejection of a kidney graft is primarily mediated by the cell-mediated immune response. This involves the activation of T cells, particularly cytotoxic T cells, which recognize the transplanted kidney as foreign tissue.
Mechanism
- Upon transplantation, the donor kidney's antigens are recognized by the recipient's T cells as non-self.
- Cytotoxic T cells are activated and target the donor kidney cells for destruction.
- This leads to inflammation and tissue damage in the transplanted kidney, ultimately causing rejection.
Role of T cells
- CD8+ cytotoxic T cells directly attack and destroy the donor kidney cells.
- CD4+ T helper cells play a role in activating other immune cells and promoting the immune response against the graft.
Prevention and treatment
- To prevent rejection, patients undergoing kidney transplantation are often prescribed immunosuppressive medications to suppress the immune response.
- In cases of acute rejection, additional immunosuppressive therapy may be required to control the immune response and salvage the graft.
In summary, the cell-mediated immune response plays a crucial role in the rejection of kidney grafts by targeting the transplanted organ as foreign tissue. Understanding and managing this immune response is essential in the success of kidney transplantation.
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Which of the following immune responses is responsible for rejection of kidney graft?a)Auto-immune responseb)Humoral immune responsec)Inflammatory immune responsed)Cell-mediated immune responseCorrect answer is option 'D'. Can you explain this answer?
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