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Which of the following forms the connecting link between glycolysis and Kreb's cycle
  • a)
    Glucose
  • b)
    Ethyl alcohol
  • c)
    Lactic acid
  • d)
    Pyruvic acid
Correct answer is option 'D'. Can you explain this answer?
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Which of the following forms the connecting link between glycolysis a...
Pyruvic acid is the end product of glycolysis. This pyruvic acid forms acetyl CoA. Acetyl CoA is an initial compound of Kreb's cycle. Glycolysis is the first step in the process of respiration, in which one glucose molecule is broken down into two molecules of pyruvate. Under aerobic conditions, the two pyruvates undergo oxidative decarboxylation to form 2 molecules of acetyl CoA that enter the Krebs cycle.
Under anaerobic conditions, pyruvates are either converted to lactic acid or ethanol. During aerobic respiration, glucose in the cytosol is converted into two moles of Pyruvic acid (a three-carbon compound). This pyruvic acid cannot enter the TCA immediately in the mitochondria. The pyruvate must be transported inside the mitochondria via a special transporter.
The PA is decarboxylated oxidatively (the process is called oxidative decarboxylation) to produce one molecule (for each PA) of CO2 and NADH, under the influence of the enzyme pyruvate dehydrogenase. The product combines with an S-containing molecule, called CoA or co-enzyme-A to form Acetyl CoA. Thus, Acetyl Co-A is the connecting link between glycolysis and Krebs cycle
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Read the passage given below and answer the following questions:Adenosine triphosphate (ATP) is the energy carrying molecule found in the cells of all living things. ATP captures chemical energy obtained from the breakdown of food molecules and releases it to fuel other cellular processes. ATP is a nucleotide that consists of three main structures: the nitrogenous base, adenine; the sugar, ribose; and a chain of three phosphate groups bound to ribose. The phosphate tail of ATP is the actual power source which the cell taps. Available energy is contained in the bonds between the phosphates and is released when they are broken, which occurs through the addition of a water molecule (a process called hydrolysis). Usually only the outer phosphate is removed from ATP to yield energy; when this occurs ATP is converted to adenosine diphosphate (ADP), the form of the nucleotide having only two phosphates.The importance of ATP (adenosine triphosphat e) as the main source of chemical energy in living matter and its involvement in cellular processes has long been recognized. The primary mechanism whereby higher organisms, including humans, generate ATP is through mitochondrial oxidative phosphorylation. For the majority of organs, the main metabolic fuel is glucose, which in the presence of oxygen undergoes complete combustion to CO2 and H2O: C6H12O6 + 6O2 → 6O2 + 6H2O + energyThe free energy (ΔG) liberated in this exergonic (ΔG is negative) reaction is partially trapped as ATP in two consecutive processes: glycolysis (cytosol) and oxidative phosphorylation (mitochondri

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Which of the following forms the connecting link between glycolysis and Kreb's cyclea)Glucoseb)Ethyl alcoholc)Lactic acidd)Pyruvic acidCorrect answer is option 'D'. Can you explain this answer?
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