Progestin-estradiol combined contraceptive pills inhibit ovulation by...
Explanation:
Progestin-estradiol combined contraceptive pills are hormonal contraceptives that contain a combination of progestin and estradiol. These hormones work together to prevent pregnancy by inhibiting ovulation, the release of an egg from the ovary.
How do progestin-estradiol combined contraceptive pills inhibit ovulation?
The combined contraceptive pills inhibit ovulation by exerting negative feedback on the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland.
1. Inhibiting the secretion of FSH and LH:
- Progestin in the contraceptive pills inhibits the secretion of FSH and LH by the pituitary gland.
- FSH is responsible for the development of the ovarian follicles during the follicular phase of the menstrual cycle.
- LH surge triggers ovulation, the release of a mature egg from the ovary.
- By inhibiting the secretion of FSH and LH, the contraceptive pills prevent the development of the ovarian follicles and the release of an egg, thereby inhibiting ovulation.
2. Negative feedback on estrogen release:
- Estrogen is released by the developing ovarian follicles during the follicular phase of the menstrual cycle.
- Estrogen is necessary for the development of the endometrium (inner lining of the uterus) and the preparation of the uterus for implantation.
- The progestin component of the contraceptive pills exerts negative feedback on the release of estrogen from the ovary.
- By inhibiting the release of estrogen, the contraceptive pills prevent the uterine physiological and morphological changes required for implantation.
Conclusion:
Therefore, the correct answer is option (c) - Progestin-estradiol combined contraceptive pills inhibit ovulation by inhibiting the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) that are necessary for ovulation. Additionally, these pills also prevent the uterine physiological and morphological changes required for implantation by exerting negative feedback on the release of estrogen from the ovary.
Progestin-estradiol combined contraceptive pills inhibit ovulation by...
Combined hormonal contraceptives consist of an estrogen and a progestogen, and act primarily by preventing ovulation through the inhibition of the follicle-stimulating hormone and luteinizing hormone. The progestogen component also renders the cervical mucus relatively impenetrable to sperm, and reduces the receptivity of the endometrium to implantation.
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