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Which enzyme is responsible for the conversion of inactive fibrinogens to fibrins?
  • a)
    Thrombin
  • b)
    Renin
  • c)
    Epinephrine
  • d)
    Thrombokinase
Correct answer is option 'A'. Can you explain this answer?
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Which enzyme is responsible for the conversion of inactive fibrinogens...
Thrombin is a naturally occurring enzyme that converts fibrinogen into fibrin, which is an integral step in clot formation. In vivo thrombin is formed from prothrombin as a result of activation of both the intrinsic and extrinsic pathways of the coagulation cascade.
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Which enzyme is responsible for the conversion of inactive fibrinogens...
Thrombin: The Enzyme Responsible for the Conversion of Fibrinogens to Fibrins
Thrombin is an enzyme that plays a crucial role in the coagulation cascade, specifically in the final step of converting fibrinogen into fibrin. This process is essential for the formation of blood clots to prevent excessive bleeding.

Conversion of Fibrinogens to Fibrins
- Fibrinogen is a soluble plasma glycoprotein that is produced by the liver and circulates in the blood.
- When there is tissue injury or damage to blood vessels, the coagulation cascade is activated.
- Thrombin is produced from prothrombin in the presence of the enzyme thrombokinase (also known as tissue factor) during the coagulation cascade.
- Thrombin then acts on fibrinogen, cleaving specific peptide bonds to form insoluble fibrin strands.
- These fibrin strands form a mesh-like network that traps blood cells and platelets to form a stable blood clot.

Importance of Thrombin in Hemostasis
- Thrombin plays a central role in hemostasis by converting fibrinogen to fibrin, which is crucial for the formation of blood clots.
- Without thrombin, the conversion of fibrinogen to fibrin would not occur, leading to an inability to form stable blood clots and increased risk of excessive bleeding.
In conclusion, thrombin is the enzyme responsible for the conversion of inactive fibrinogens to fibrins during the coagulation cascade, playing a critical role in hemostasis and preventing excessive bleeding.
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Which enzyme is responsible for the conversion of inactive fibrinogens to fibrins?a)Thrombinb)Reninc)Epinephrined)ThrombokinaseCorrect answer is option 'A'. Can you explain this answer?
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