The site of production of ADA in the body is:

Answer: C) Blood plasma

The production of adenosine deaminase (ADA) occurs primarily in the blood plasma. ADA is an enzyme that plays a crucial role in purine metabolism by converting adenosine and deoxyadenosine into inosine and deoxyinosine, respectively. This conversion is essential in preventing the accumulation of toxic purine metabolites in the body.

Explanation:

1. Adenosine Deaminase (ADA) Overview:
- ADA is an enzyme that catalyzes the deamination of adenosine and deoxyadenosine.
- It converts adenosine to inosine and deoxyadenosine to deoxyinosine, which are less toxic than their respective precursors.
- ADA is involved in purine metabolism, ensuring the proper breakdown and elimination of purine nucleosides.

2. ADA Production:
- ADA is primarily produced and secreted by lymphocytes, specifically T-lymphocytes.
- T-lymphocytes are a type of white blood cell that plays a crucial role in the immune response.
- ADA production occurs within the cytoplasm of T-lymphocytes and is subsequently released into the blood plasma.

3. Distribution and Function:
- Once produced and released into the blood plasma, ADA circulates throughout the body.
- ADA is essential for the maintenance of normal immune function.
- It helps regulate the levels of adenosine and deoxyadenosine, preventing their accumulation and subsequent toxicity.
- By eliminating excess purine nucleosides, ADA ensures the proper functioning of various physiological processes, including DNA synthesis, energy metabolism, and neurotransmission.

4. ADA Deficiency:
- ADA deficiency, a genetic disorder characterized by reduced or absent ADA activity, can lead to severe immunodeficiency.
- Individuals with ADA deficiency are more susceptible to recurrent infections and may experience impaired growth and development.
- Treatment options for ADA deficiency include enzyme replacement therapy, gene therapy, and hematopoietic stem cell transplantation.

In summary, the primary site of production of ADA in the body is the blood plasma. ADA is produced by T-lymphocytes and plays a crucial role in purine metabolism, ensuring the proper breakdown and elimination of adenosine and deoxyadenosine. Its deficiency can result in severe immunodeficiency.

(b) Lymphocytes