The function of IgE isa)Protection from inhaled/ingested pathogensb)Me...
The function of IgE antibody as mediators in allergic reactions of Type I is explained by their ability to interact both with antigen and with receptor molecules on the membrane of blood basophils and tissue mast cells. However, it is not understood how the interaction of an allergen with cell-bound IgE antibody will induce basophil (mast) cells to release a great number of biologically active substances of which some will be further discussed at this meeting, nor is it known what role the IgE-mast cell system plays in the development and control of a normal immune response.
The function of IgE isa)Protection from inhaled/ingested pathogensb)Me...
Function of IgE:
IgE or Immunoglobulin E is a type of antibody that plays a crucial role in the allergic response of the body.
Mediation in Allergic Response:
IgE antibodies are produced by B cells in response to an allergen such as pollen, dust, or certain foods. These antibodies bind to mast cells and basophils in tissues such as the skin, lungs, and gastrointestinal tract. When the allergen enters the body again, it binds to the IgE antibodies on the mast cells and basophils, causing them to release histamine and other chemicals. These chemicals cause the symptoms of an allergic reaction, such as itching, swelling, and inflammation.
Role in Asthma:
In people with asthma, IgE plays a key role in triggering symptoms such as wheezing, coughing, and shortness of breath. When an asthma trigger such as dust or exercise is inhaled, it can stimulate the production of IgE antibodies. These antibodies then bind to mast cells and basophils in the airways, causing the release of histamine and other chemicals that result in airway inflammation and constriction.
Role in Anaphylaxis:
In severe cases, IgE-mediated allergic reactions can lead to anaphylaxis, a life-threatening condition that causes the body to go into shock. Anaphylaxis can be triggered by foods, medications, insect stings, and other allergens. During anaphylaxis, IgE antibodies cause the release of large amounts of histamine and other chemicals, leading to symptoms such as difficulty breathing, low blood pressure, and loss of consciousness.
Treatment of Allergic Diseases:
Because IgE plays such a central role in allergic reactions, drugs that target IgE have been developed as treatments for allergic diseases such as asthma and allergic rhinitis. One such drug is omalizumab, a monoclonal antibody that binds to IgE and prevents it from triggering the release of histamine and other chemicals. Omalizumab has been shown to be effective in reducing asthma symptoms and improving lung function in people with severe asthma.