1.The pairing of bases in RNA is A-U where as in DNA it is A-T.
2.DNA is stable in alkaline conditions but RNA is not.

Chemical Differences between DNA and RNA:

1. Sugar Composition:
- The main chemical difference between DNA and RNA lies in their sugar composition. DNA contains deoxyribose sugar, which has one less oxygen atom compared to the ribose sugar found in RNA. This difference gives DNA its name, as "deoxy" refers to the absence of one oxygen atom.
- The presence of deoxyribose in DNA makes it more stable than RNA, as the extra oxygen atom in ribose can make RNA more prone to degradation.

2. Nitrogenous Bases:
- Another key chemical difference between DNA and RNA is the type of nitrogenous bases they contain. Both DNA and RNA have four nitrogenous bases, but RNA contains uracil instead of thymine found in DNA.
- This difference in nitrogenous bases affects the genetic information stored in DNA and RNA. Thymine pairs with adenine in DNA, while uracil pairs with adenine in RNA during transcription and translation processes.
In summary, the two main chemical differences between DNA and RNA are in their sugar composition and nitrogenous bases. These distinctions play crucial roles in the stability and genetic functions of DNA and RNA in living organisms.