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Consider the following human disorders:
i. Haemophilia  
ii. Down’s Syndrome
iii. Cystic fibrosis
iv. Colour blindness
v. Night blindness.
Which of these disorders exhibit ‘Mendelian’ pattern of inheritance?
  • a)
    ii, iii and iv
  • b)
    i, ii and iii
  • c)
    i, iii and v
  • d)
    i, iii and iv 
Correct answer is option 'D'. Can you explain this answer?
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Understanding Mendelian Inheritance
Mendelian inheritance refers to the patterns of inheritance that are characteristic of organisms following the principles set forth by Gregor Mendel. The disorders listed can be categorized based on their inheritance patterns.
Disorders and Their Inheritance Patterns
- Haemophilia:
- This is an X-linked recessive disorder.
- It predominantly affects males, as they have only one X chromosome.
- Down’s Syndrome:
- This condition is caused by chromosomal aneuploidy (trisomy 21) rather than a Mendelian trait.
- It does not follow a simple Mendelian inheritance pattern.
- Cystic Fibrosis:
- An autosomal recessive disorder.
- It requires two copies of the mutated gene to express the disease.
- Colour Blindness:
- This is an X-linked recessive trait.
- Similar to haemophilia, it primarily affects males.
- Night Blindness:
- This can be inherited in various ways, but some forms, such as those linked to Vitamin A deficiency, do not strictly follow Mendelian inheritance.
Conclusion
From the analysis:
- Haemophilia and Colour Blindness are X-linked recessive disorders.
- Cystic Fibrosis is an autosomal recessive disorder.
- Night Blindness can exhibit Mendelian traits, depending on the specific type, but it is less clear-cut.
Thus, the correct option is d) i, iii, and iv, as these disorders exhibit clear Mendelian patterns of inheritance.
Summary
- i. Haemophilia: X-linked recessive
- ii. Down’s Syndrome: Not Mendelian
- iii. Cystic Fibrosis: Autosomal recessive
- iv. Colour Blindness: X-linked recessive
- v. Night Blindness: Variable inheritance
This understanding helps clarify the inheritance of these disorders in genetic counseling and medical genetics.
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Consider the following human disorders:i. Haemophilia ii. Down’s Syndromeiii. Cystic fibrosisiv. Colour blindnessv. Night blindness.Which of these disorders exhibit ‘Mendelian’ pattern of inheritance?a)ii, iii and ivb)i, ii and iiic)i, iii and vd)i, iii and ivCorrect answer is option 'D'. Can you explain this answer?
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