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 The two polypeptides of human insulin are linked together by         [2016]
  • a)
    hydrogen bonds
  • b)
    phosphodiester bond
  • c)
    covalent bond
  • d)
    disulphide bridges 
Correct answer is option 'D'. Can you explain this answer?
Verified Answer
The two polypeptides of human insulin are linked together by [2016]...
(d) Insulin is a hormone consisting of 2 polypeptide chains. Each chain is composed of a specific sequence of amino acid residues connected by peptide bonds. In humans, chain A has 21 amino acids, and chain B has 30. Post translational modifications result in the connection of these two chains by disulfide bridges. Cysteine residues on A7 and B7, as well as A20 to B19 are covalently connected by disulfide bridges
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Most Upvoted Answer
The two polypeptides of human insulin are linked together by [2016]...
Insulin is a hormone secreted by the beta cells of the pancreas. It is composed of two polypeptide chains, A and B, linked together by disulfide bonds.

Explanation:
Insulin is a polypeptide hormone consisting of two chains, A and B, which are linked by two disulfide bonds. The A chain has 21 amino acids, while the B chain has 30. These chains are linked together by disulfide bridges between cysteine residues.

Disulfide bonds are covalent bonds that are formed between two cysteine residues in a polypeptide chain. These bonds are formed by the oxidation of two thiol groups (-SH) on the cysteine residues. Disulfide bonds are strong and stable, and they play an important role in stabilizing the tertiary and quaternary structures of proteins.

In the case of insulin, the disulfide bonds between the A and B chains are essential for the proper folding and biological activity of the hormone. Without these bonds, insulin would not be able to bind to its receptor and carry out its functions in the body.

Therefore, the correct answer is option D, i.e., disulfide bridges.
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The two polypeptides of human insulin are linked together by [2016]a)hydrogen bondsb)phosphodiester bondc)covalent bondd)disulphide bridgesCorrect answer is option 'D'. Can you explain this answer?
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