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Select the option which is not correct with respect to enzyme action:          [2014]
  • a)
    Substrate binds with enzyme at its active site.
  • b)
    Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
  • c)
    A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.
  • d)
    Malonate is a competitive inhibitor of succinic dehydrogenase. 
Correct answer is option 'B'. Can you explain this answer?
Verified Answer
Select the option which is not correct with respect to enzyme action: ...
(b) Inhibitions of succinic dehydrogenase by malonate is an example of competitive inhibition. Thus it is reversible reaction. On increasing the substrate (succinate) concentration the effect of inhibitor is removed and Vmax  remain same. 
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Most Upvoted Answer
Select the option which is not correct with respect to enzyme action: ...
Enzyme Action:

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are highly specific and work by binding with their respective substrates at their active sites. Enzyme action can be affected by various factors like pH, temperature, inhibitors, etc.

Options:

a) Substrate binds with enzyme at its active site: This statement is correct. The substrate binds to the enzyme's active site, forming an enzyme-substrate complex.

b) Addition of a lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate: This statement is NOT correct. Malonate is a competitive inhibitor of succinic dehydrogenase, which means it competes with the substrate (succinate) for binding with the enzyme's active site. If a large amount of succinate is added, it can outcompete malonate and reverse the inhibition.

c) A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate: This statement is correct. Non-competitive inhibitors bind to the enzyme at a different site than the active site, changing the enzyme's shape and preventing substrate binding.

d) Malonate is a competitive inhibitor of succinic dehydrogenase: This statement is correct. Malonate competes with the substrate for binding with the enzyme's active site, reducing the rate of the reaction.

Conclusion:

The correct option is (b) because adding a large amount of succinate can reverse the inhibition of succinic dehydrogenase by malonate.
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Community Answer
Select the option which is not correct with respect to enzyme action: ...
B) is incorrect with respect to enzyme action because addition of a lot of succinate reverse the inhibition of succinic dehydrogenase by malonate. Inhibition of succinic dehydrogenase by malonate is an example of competitive inhibition.

Competitive inhibition occurs when enzyme and inhibitor both have more or less similar structure and are present in higher concentration.

Thus, both enzyme and inhibitor for compete for the active site of enzyme resulting in the decrease of the enzymatic activity.
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Select the option which is not correct with respect to enzyme action: [2014]a)Substrate binds with enzyme at its active site.b)Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.c)A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.d)Malonate is a competitive inhibitor of succinic dehydrogenase.Correct answer is option 'B'. Can you explain this answer?
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Select the option which is not correct with respect to enzyme action: [2014]a)Substrate binds with enzyme at its active site.b)Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.c)A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.d)Malonate is a competitive inhibitor of succinic dehydrogenase.Correct answer is option 'B'. Can you explain this answer? for NEET 2024 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Select the option which is not correct with respect to enzyme action: [2014]a)Substrate binds with enzyme at its active site.b)Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.c)A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.d)Malonate is a competitive inhibitor of succinic dehydrogenase.Correct answer is option 'B'. Can you explain this answer? covers all topics & solutions for NEET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Select the option which is not correct with respect to enzyme action: [2014]a)Substrate binds with enzyme at its active site.b)Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.c)A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.d)Malonate is a competitive inhibitor of succinic dehydrogenase.Correct answer is option 'B'. Can you explain this answer?.
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