Of a normal couple, half the sons are haemophilic while half the daugh...
Since half the sons are haemophilic so the genes for haemophilia is located on X-chromosome of mother.
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Of a normal couple, half the sons are haemophilic while half the daugh...
Explanation:
The inheritance of hemophilia, a blood clotting disorder, is linked to the X-chromosome. Hemophilia is a recessive disorder, meaning that an individual must inherit two copies of the defective gene (one from each parent) to express the disorder.
Normal couple:
A normal couple consists of a male (XY) and a female (XX). The male has one X-chromosome and one Y-chromosome, while the female has two X-chromosomes.
Inheritance of hemophilia:
- Hemophilia is caused by a defective gene located on the X-chromosome.
- Females have two X-chromosomes, so even if one X-chromosome carries the defective gene, the other X-chromosome can compensate for it, resulting in carrier status. Carriers do not express the disorder but can pass it on to their offspring.
- Males have one X-chromosome and one Y-chromosome. If their X-chromosome carries the defective gene, they will express the disorder because they do not have another X-chromosome to compensate for it.
Percentage of affected offspring:
- In a normal couple, the probability of a son inheriting the defective gene and expressing the disorder is 50% because he can only inherit the defective gene from his mother.
- The probability of a daughter inheriting the defective gene and being a carrier is also 50% because she can inherit the defective gene from either her mother or her father.
Correct answer:
The correct answer is option 'C' - the defective gene is located on one X-chromosome of the mother. This is because the mother passes one of her X-chromosomes to each of her offspring. If the mother carries the defective gene on one of her X-chromosomes, there is a 50% chance that she will pass it on to her sons, making them hemophilic. Daughters have a 50% chance of inheriting the defective gene from their mother, making them carriers.