Toxicity of drug on human can be studied by using transgenic animal by...
Toxicity of drug on human can be studied by using transgenic animal by Inoculating gene that make them more sensitive to toxic substances and exposing to toxic substance to be studied.
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Toxicity of drug on human can be studied by using transgenic animal by...
Transgenic animals for studying drug toxicity
Transgenic animals are animals that have been genetically modified to contain one or more genes from another species. These animals are used to study the effects of drugs on human biology. One of the ways that transgenic animals can be used to study drug toxicity is by inoculating them with genes that make them more sensitive to toxic substances.
Inoculating gene for sensitivity to toxic substances
The inoculation of genes can be done in a variety of ways, but one of the most common methods is through the use of viral vectors. Viral vectors are viruses that have been modified to carry specific genes into a host cell. Once the virus enters the cell, it inserts the gene into the host's DNA, where it can be expressed and studied.
When transgenic animals are inoculated with genes that make them more sensitive to toxic substances, they can be used to study the effects of drugs on human biology. For example, if a drug is known to be toxic to the liver, researchers can inoculate transgenic animals with a gene that makes their liver more susceptible to damage. They can then administer the drug to the animals and study the effects on the liver.
Advantages of using transgenic animals
There are several advantages to using transgenic animals to study drug toxicity. For one, they allow researchers to study the effects of drugs on human biology without having to use human subjects. This can help to reduce the risk of harm to humans and can also help to speed up the drug development process.
Transgenic animals can also be used to study the effects of drugs in a controlled environment. For example, researchers can control the dosage of the drug and the length of time that the animals are exposed to it. This can help to provide more accurate and reliable data on the toxicity of the drug.
Conclusion
In conclusion, transgenic animals can be used to study the effects of drugs on human biology. By inoculating them with genes that make them more sensitive to toxic substances, researchers can gain valuable insights into the toxicity of drugs and their effects on human health. While there are some limitations to this approach, it remains an important tool for drug development and research.
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