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Skin colour in mice is an example of –
  • a)
    recessive epistatis
  • b)
    dominant epistatis
  • c)
    polygenic inheritance
  • d)
    pleiotropy
Correct answer is option 'A'. Can you explain this answer?
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Skin colour in mice is an example of –a)recessive epistatisb)dom...
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Skin colour in mice is an example of –a)recessive epistatisb)dom...
Epistasis” is a word composed of Greek roots meaning “standing upon.” The alleles that are being masked or silenced are said to be hypostatic to the epistatic alleles that are doing the masking. Often the biochemical basis of epistasis is a gene pathway in which expression of one gene is dependent on the function of a gene that precedes or follows it in the pathway.

An example of epistasis is pigmentation in mice. The wild-type coat color, agouti (AA) is dominant to solid-colored fur (aa). However, a separate gene C, when present as the recessive homozygote (cc), negates any expression of pigment from the A gene and results in an albino mouse . Therefore, the genotypes AAcc, Aacc, and aacc all produce the same albino phenotype. A cross between heterozygotes for both genes (AaCc x AaCc) would generate offspring with a phenotypic ratio of 9 agouti:3 black:4 albino . In this case, the C gene is epistatic to the A gene.
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Skin colour in mice is an example of –a)recessive epistatisb)dominant epistatisc)polygenic inheritanced)pleiotropyCorrect answer is option 'A'. Can you explain this answer?
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