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It is important that certain free ribosomes bind to the outer surface on the endoplasmic reticulum (ER) in order to complete their protein synthesis because:
  • a)
    The ER membrane will break down without the presence of numerous ribosomes, 
  • b)
    It allows the synthesis of certain proteins to be completed in the cytosol, 
  • c)
    It prevents the possibility that the synthesis of certain proteins, such as lysosomal hydrolases, would go to completion in the cytoplasm.
  • d)
    Mitochondrial ribosomes must transcribe proteins encoded by mitochondrial DNA in this manner.
Correct answer is option 'C'. Can you explain this answer?
Verified Answer
It is important that certain free ribosomes bind to the outer surface ...
Many proteins must be deposited into the ER lumen (membranous sacs) as they are made. Some of these are to be secreted out of the cell and must start their journey in the ER; others are simply too dangerous to synthesise in the cell’s cytoplasm (cytosol), such as lysosomal hydrolases that would digest away parts of the cell if allowed to freely float around the cell after synthesis. 
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Most Upvoted Answer
It is important that certain free ribosomes bind to the outer surface ...
Explanation:
The correct answer is option 'C': It prevents the possibility that the synthesis of certain proteins, such as lysosomal hydrolases, would go to completion in the cytoplasm.

Reasoning:
The endoplasmic reticulum (ER) is an organelle involved in the synthesis, folding, and modification of proteins in eukaryotic cells. It consists of a network of tubules and flattened sacs called cisternae. The ER can be divided into two regions: the rough endoplasmic reticulum (RER), which has ribosomes attached to its surface, and the smooth endoplasmic reticulum (SER), which lacks ribosomes.

- Ribosomes: Ribosomes are cellular structures responsible for protein synthesis. They can exist as free ribosomes in the cytosol or bound ribosomes attached to the ER membrane. Free ribosomes synthesize proteins that will function in the cytosol or other organelles, whereas bound ribosomes synthesize proteins destined for secretion, insertion into the plasma membrane, or localization in the endomembrane system.

- Lysosomal Hydrolases: Lysosomal hydrolases are a group of enzymes responsible for the degradation of various macromolecules in the lysosomes. These enzymes are synthesized in the RER and are targeted to the lysosomes for their proper function. If the synthesis of lysosomal hydrolases were to go to completion in the cytoplasm, it would disrupt the normal functioning of the cell as these enzymes are meant to be localized within the lysosomes.

- Preventing Completion in the Cytoplasm: By binding to the outer surface of the ER, certain free ribosomes ensure that the synthesis of lysosomal hydrolases and other proteins destined for the endomembrane system is completed within the ER lumen. This is important for the proper folding, modification, and trafficking of these proteins to their final destinations. If these proteins were to be synthesized in the cytoplasm, they would not undergo the necessary modifications and would not be targeted to the appropriate organelles.

In summary, the presence of certain free ribosomes binding to the outer surface of the ER prevents the synthesis of certain proteins, such as lysosomal hydrolases, from going to completion in the cytoplasm. This ensures that these proteins undergo proper folding, modification, and trafficking to their respective organelles, maintaining the normal functioning of the cell.
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It is important that certain free ribosomes bind to the outer surface on the endoplasmic reticulum (ER) in order to complete their protein synthesis because:a)The ER membrane will break down without the presence of numerous ribosomes,b)It allows the synthesis of certain proteins to be completed in the cytosol,c)It prevents the possibility that the synthesis of certain proteins, such as lysosomal hydrolases, would go to completion in the cytoplasm.d)Mitochondrial ribosomes must transcribe proteins encoded by mitochondrial DNA in this manner.Correct answer is option 'C'. Can you explain this answer?
Question Description
It is important that certain free ribosomes bind to the outer surface on the endoplasmic reticulum (ER) in order to complete their protein synthesis because:a)The ER membrane will break down without the presence of numerous ribosomes,b)It allows the synthesis of certain proteins to be completed in the cytosol,c)It prevents the possibility that the synthesis of certain proteins, such as lysosomal hydrolases, would go to completion in the cytoplasm.d)Mitochondrial ribosomes must transcribe proteins encoded by mitochondrial DNA in this manner.Correct answer is option 'C'. Can you explain this answer? for NEET 2024 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about It is important that certain free ribosomes bind to the outer surface on the endoplasmic reticulum (ER) in order to complete their protein synthesis because:a)The ER membrane will break down without the presence of numerous ribosomes,b)It allows the synthesis of certain proteins to be completed in the cytosol,c)It prevents the possibility that the synthesis of certain proteins, such as lysosomal hydrolases, would go to completion in the cytoplasm.d)Mitochondrial ribosomes must transcribe proteins encoded by mitochondrial DNA in this manner.Correct answer is option 'C'. Can you explain this answer? covers all topics & solutions for NEET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for It is important that certain free ribosomes bind to the outer surface on the endoplasmic reticulum (ER) in order to complete their protein synthesis because:a)The ER membrane will break down without the presence of numerous ribosomes,b)It allows the synthesis of certain proteins to be completed in the cytosol,c)It prevents the possibility that the synthesis of certain proteins, such as lysosomal hydrolases, would go to completion in the cytoplasm.d)Mitochondrial ribosomes must transcribe proteins encoded by mitochondrial DNA in this manner.Correct answer is option 'C'. Can you explain this answer?.
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