Introduction
Cis-platin is a chemotherapy drug used to treat various types of cancer. When it enters the human body, it undergoes hydrolysis and forms a diaqua complex. This complex then modifies the DNA structure by binding to specific sites.

Binding to DNA
Cis-platin binds to the purine bases of DNA, primarily guanine, forming a covalent bond. This bond leads to the formation of intrastrand and interstrand cross-links in the DNA structure. These cross-links prevent DNA replication, transcription, and repair, leading to cell death.

Effects on Cancer Cells
Cis-platin is highly effective against rapidly dividing cancer cells. The drug's ability to bind to DNA and form cross-links disrupts the cancer cells' ability to undergo cell division, leading to their death. Cis-platin is particularly effective against testicular, ovarian, bladder, and lung cancers.

Side Effects
Cis-platin can also affect normal, healthy cells that undergo rapid division, such as cells in the digestive tract and hair follicles. This can lead to side effects such as nausea, vomiting, hair loss, and gastrointestinal problems.

Conclusion
Cis-platin is a powerful chemotherapy drug that modifies DNA by binding to specific sites. Its ability to form cross-links in the DNA structure disrupts the cancer cells' ability to divide, leading to their death. While effective against cancer, cis-platin can also have side effects on normal, healthy cells.

DNA is ur ans..as i think..