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- a)Sickle cell anaemia - Autosomal recessive trait, chromosome - 11
- b)Thalassemia - X linked
- c)Haemophilia - Y linked
- d)Phenylketonuria - Autosomal dominant trait
Correct answer is option 'A'. Can you explain this answer?
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Select the correct matcha)Sickle cell anaemia - Autosomal recessive tr...
Sickle cell anaemia - Autosomal recessive trait, chromosome - 11
Sickle cell anaemia is a genetic disorder characterized by the presence of abnormal hemoglobin, resulting in the production of sickle-shaped red blood cells. It is inherited in an autosomal recessive manner, which means that both copies of the gene responsible for the disorder must be mutated in order for an individual to be affected. Let's explore this answer in detail.
Autosomal Recessive Inheritance:
- Autosomal inheritance refers to the inheritance of a trait or disorder that is located on one of the non-sex chromosomes (autosomes), in this case, chromosome 11.
- Recessive inheritance means that an individual must inherit two copies of the mutated gene (one from each parent) in order to express the disorder.
- In the case of sickle cell anaemia, the mutated gene is located on chromosome 11 and is responsible for the production of abnormal hemoglobin.
Explanation:
- Sickle cell anaemia is caused by a mutation in the HBB gene, which codes for the beta-globin subunit of hemoglobin.
- This mutation leads to the production of abnormal hemoglobin, known as hemoglobin S, which causes red blood cells to become sickle-shaped under certain conditions.
- The HBB gene is located on chromosome 11, and individuals with sickle cell anaemia inherit two copies of the mutated gene, one from each parent.
- If an individual inherits only one copy of the mutated gene, they are said to be carriers of the sickle cell trait, which means they have a higher resistance to malaria but do not exhibit the symptoms of sickle cell anaemia.
Significance of Chromosome 11:
- Chromosome 11 is one of the 23 pairs of chromosomes found in humans.
- It contains many genes that are involved in various biological processes and traits.
- The HBB gene, responsible for the production of hemoglobin, is located on chromosome 11.
Conclusion:
In conclusion, sickle cell anaemia is an autosomal recessive disorder caused by a mutation in the HBB gene located on chromosome 11. It is inherited when both copies of the gene are mutated, resulting in the production of abnormal hemoglobin and the characteristic sickle-shaped red blood cells.
Sickle cell anaemia is a genetic disorder characterized by the presence of abnormal hemoglobin, resulting in the production of sickle-shaped red blood cells. It is inherited in an autosomal recessive manner, which means that both copies of the gene responsible for the disorder must be mutated in order for an individual to be affected. Let's explore this answer in detail.
Autosomal Recessive Inheritance:
- Autosomal inheritance refers to the inheritance of a trait or disorder that is located on one of the non-sex chromosomes (autosomes), in this case, chromosome 11.
- Recessive inheritance means that an individual must inherit two copies of the mutated gene (one from each parent) in order to express the disorder.
- In the case of sickle cell anaemia, the mutated gene is located on chromosome 11 and is responsible for the production of abnormal hemoglobin.
Explanation:
- Sickle cell anaemia is caused by a mutation in the HBB gene, which codes for the beta-globin subunit of hemoglobin.
- This mutation leads to the production of abnormal hemoglobin, known as hemoglobin S, which causes red blood cells to become sickle-shaped under certain conditions.
- The HBB gene is located on chromosome 11, and individuals with sickle cell anaemia inherit two copies of the mutated gene, one from each parent.
- If an individual inherits only one copy of the mutated gene, they are said to be carriers of the sickle cell trait, which means they have a higher resistance to malaria but do not exhibit the symptoms of sickle cell anaemia.
Significance of Chromosome 11:
- Chromosome 11 is one of the 23 pairs of chromosomes found in humans.
- It contains many genes that are involved in various biological processes and traits.
- The HBB gene, responsible for the production of hemoglobin, is located on chromosome 11.
Conclusion:
In conclusion, sickle cell anaemia is an autosomal recessive disorder caused by a mutation in the HBB gene located on chromosome 11. It is inherited when both copies of the gene are mutated, resulting in the production of abnormal hemoglobin and the characteristic sickle-shaped red blood cells.
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Select the correct matcha)Sickle cell anaemia - Autosomal recessive trait, chromosome - 11b)Thalassemia - X linkedc)Haemophilia - Y linkedd)Phenylketonuria - Autosomal dominant traitCorrect answer is option 'A'. Can you explain this answer?
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