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Predict the effect of the following structural changes on the sympathomimetic activity of phenyl ethanolamines. Support your answer with relevant structures 1. Replacement of catechol by resorcinol moiety. 2. Replacement of one of the ring hydroxyl function with hydroxymethyl function. 3. Introduction of isopropyl group on the amine nitrogen 4. Removal of 3-OH function in the catechol nucleus 5. Introduction of t-butyl group on the amine nitrogen 6. Absence of hydroxyl group on aromatic ring?
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Predict the effect of the following structural changes on the sympatho...

Effect of Structural Changes on Sympathomimetic Activity of Phenyl Ethanolamines:

1. Replacement of catechol by resorcinol moiety:
- The replacement of catechol by resorcinol moiety is likely to decrease the sympathomimetic activity of phenyl ethanolamines. This is because the catechol moiety is essential for activity as it plays a crucial role in binding to adrenergic receptors.

2. Replacement of one of the ring hydroxyl function with hydroxymethyl function:
- The replacement of one of the ring hydroxyl functions with a hydroxymethyl function is likely to decrease the sympathomimetic activity. Hydroxyl groups are important for receptor binding and altering their position may affect the interaction with adrenergic receptors.

3. Introduction of isopropyl group on the amine nitrogen:
- The introduction of an isopropyl group on the amine nitrogen may increase the lipophilicity of the compound, leading to enhanced penetration through biological membranes. This could potentially increase the sympathomimetic activity by improving the compound's pharmacokinetic properties.

4. Removal of 3-OH function in the catechol nucleus:
- The removal of the 3-OH function in the catechol nucleus is likely to significantly reduce the sympathomimetic activity. The 3-OH group is crucial for hydrogen bonding with adrenergic receptors, and its absence may result in decreased receptor binding affinity.

5. Introduction of t-butyl group on the amine nitrogen:
- The introduction of a t-butyl group on the amine nitrogen may increase steric hindrance and reduce the ability of the compound to interact with adrenergic receptors. This could lead to a decrease in sympathomimetic activity.

6. Absence of hydroxyl group on aromatic ring:
- The absence of a hydroxyl group on the aromatic ring may significantly reduce the sympathomimetic activity of phenyl ethanolamines. Hydroxyl groups are crucial for hydrogen bonding with adrenergic receptors, and their absence could lead to decreased receptor binding affinity and ultimately decreased activity.
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Predict the effect of the following structural changes on the sympathomimetic activity of phenyl ethanolamines. Support your answer with relevant structures 1. Replacement of catechol by resorcinol moiety. 2. Replacement of one of the ring hydroxyl function with hydroxymethyl function. 3. Introduction of isopropyl group on the amine nitrogen 4. Removal of 3-OH function in the catechol nucleus 5. Introduction of t-butyl group on the amine nitrogen 6. Absence of hydroxyl group on aromatic ring?
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Predict the effect of the following structural changes on the sympathomimetic activity of phenyl ethanolamines. Support your answer with relevant structures 1. Replacement of catechol by resorcinol moiety. 2. Replacement of one of the ring hydroxyl function with hydroxymethyl function. 3. Introduction of isopropyl group on the amine nitrogen 4. Removal of 3-OH function in the catechol nucleus 5. Introduction of t-butyl group on the amine nitrogen 6. Absence of hydroxyl group on aromatic ring? for NEET 2024 is part of NEET preparation. The Question and answers have been prepared according to the NEET exam syllabus. Information about Predict the effect of the following structural changes on the sympathomimetic activity of phenyl ethanolamines. Support your answer with relevant structures 1. Replacement of catechol by resorcinol moiety. 2. Replacement of one of the ring hydroxyl function with hydroxymethyl function. 3. Introduction of isopropyl group on the amine nitrogen 4. Removal of 3-OH function in the catechol nucleus 5. Introduction of t-butyl group on the amine nitrogen 6. Absence of hydroxyl group on aromatic ring? covers all topics & solutions for NEET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Predict the effect of the following structural changes on the sympathomimetic activity of phenyl ethanolamines. Support your answer with relevant structures 1. Replacement of catechol by resorcinol moiety. 2. Replacement of one of the ring hydroxyl function with hydroxymethyl function. 3. Introduction of isopropyl group on the amine nitrogen 4. Removal of 3-OH function in the catechol nucleus 5. Introduction of t-butyl group on the amine nitrogen 6. Absence of hydroxyl group on aromatic ring?.
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