How many factors shift the oxygen dissociation curve to the right shi...
Each haemoglobin molecule can carry a maximum of four molecules of O
2. Binding of oxygen with haemoglobin is primarily related to partial pressure of O
2. Partial pressure of CO
2, hydrogen ion concentration and temperature are the other factors which can interfere with this binding. A sigmoid curve is obtained when percentage saturation of haemoglobin with O
2 is plotted against the pO
2. This curve is called the Oxygen dissociation curve and is highly useful in studying the effect of factors like pCO
2, H
+ concentration, etc., on binding of O
2 with haemoglobin. In the alveoli, where there is high pO
2, low pCO
2, lesser H
+ concentration and lower temperature, the factors are all favourable for the formation of oxyhaemoglobin, whereas in the tissues, where low pO
2, high pCO
2, high H
+ concentration and higher temperature exist, the conditions are favourable for dissociation of oxygen from the oxyhaemoglobin.
A shift of the curve to the right indicates decreased affinity of the haemoglobin for oxygen and hence an increased tendency to give up oxygen to the tissues. A shift to the left indicates increased affinity and so an increased tendency for haemoglobin to take up and retain oxygen.
The effect of this rightward shift of the curve increases the partial pressure of oxygen in the tissues when it is most needed, such as during exercise, or hemorrhagic shock. In contrast, the curve is shifted to the left by the opposite of these conditions.