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The process of a muscle contracting is a complex process. Which of the following statements does not characterise muscle contraction in humans?
  • a)
    A nervous impulse comes at the neuromuscular junction and from the terminal, acetylcholine is released.
  • b)
    In the presence of high concentrations of calcium, the calcium binds to tropomyosin.
  • c)
    The breakdown of ATP helps in the shortening of the muscle.
  • d)
    The myosin leaves the actin and the cross-bridge is broken when an ATP molecule binds to the myosin head.
Correct answer is option 'B'. Can you explain this answer?
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The process of a muscle contracting is a complex process. Which of th...
Muscle Contraction in Humans

Muscle contraction is a complex process that involves the interaction of various proteins and molecules in the muscle fibers. The following statements characterize muscle contraction in humans:

A) Nervous Impulse and Acetylcholine Release

- A nervous impulse travels down a motor neuron to the neuromuscular junction.
- At the neuromuscular junction, the nerve impulse triggers the release of a neurotransmitter called acetylcholine.
- Acetylcholine diffuses across the synaptic cleft and binds to receptors on the muscle fiber membrane.
- This binding opens ion channels, which allows the entry of positively charged ions into the muscle fiber, leading to depolarization.

B) Calcium Binding to Tropomyosin

- Calcium ions are released from the sarcoplasmic reticulum into the muscle fiber in response to depolarization.
- The calcium ions bind to a protein called troponin, which causes a conformational change in another protein called tropomyosin.
- This conformational change exposes the binding sites on actin, the thin filament in muscle fibers.

C) ATP Breakdown and Muscle Shortening

- The myosin head, which is part of the thick filament in muscle fibers, binds to the exposed binding sites on actin.
- The myosin head undergoes a conformational change, which pulls the actin filament toward the center of the sarcomere, the basic unit of muscle contraction.
- This process requires energy in the form of ATP, which is hydrolyzed by the myosin head.
- The breakdown of ATP to ADP and inorganic phosphate releases energy, which is used to power the movement of the myosin head.

D) Myosin-Actin Cross-Bridge and ATP Binding

- Once the myosin head has pulled the actin filament, it remains attached to actin in a state called the myosin-actin cross-bridge.
- Another ATP molecule binds to the myosin head, causing it to detach from actin.
- The ATP is then hydrolyzed to ADP and inorganic phosphate, which resets the myosin head to its original conformation and prepares it for another cycle of cross-bridge formation and detachment.

Correct Answer: B) In the presence of high concentrations of calcium, the calcium binds to tropomyosin.

Explanation:

Option B is incorrect because calcium ions do not bind to tropomyosin directly, but rather to the protein troponin, which is positioned on the actin filament adjacent to tropomyosin. The binding of calcium to troponin causes a conformational change in tropomyosin, which exposes the binding sites on actin for myosin binding.
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The process of a muscle contracting is a complex process. Which of th...
This is the wrong statement. In the presence of high concentrations of Ca2+, the Ca2+ binds to troponin, changing its shape and so moving tropomyosin from the active site of the actin. The myosin filaments can now attach to the actin, forming a cross-bridge.
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The process of a muscle contracting is a complex process. Which of the following statements does not characterise muscle contraction in humans?a)A nervous impulse comes at the neuromuscular junction and from the terminal, acetylcholine is released.b)In the presence of high concentrations of calcium, the calcium binds to tropomyosin.c)The breakdown of ATP helps in the shortening of the muscle.d)The myosin leaves the actin and the cross-bridge is broken when an ATP molecule binds to the myosin head.Correct answer is option 'B'. Can you explain this answer?
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