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How does sickle cell anemia provide immunity against malaria among African population ?
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How does sickle cell anemia provide immunity against malaria among Afr...
S.C.A is an autosomal recessive disorder It is lethal in homozygous condition but it provide resistance against malarian parasite of plasmodium is not capable to attach properly on the surface of RBC thus it can not penetrate and a life cycle remain incompletedSickle cell anaemia carrier that is HbA&HbS, S.C.A are naturally selected in African population bcz it shows increase resistance against a plasmodium falciparum
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How does sickle cell anemia provide immunity against malaria among Afr...
Sickle cell anemia is an autosomal hereditary disorder in which erthrocytes become sickle shaped. The disorder is caused by formation of an abnormal haemoglobin called haemoglobin -S. As found out by Ingram, haemoglobin -S differs from normal haemoglobin-A in only one amino acid -6th amino acid of beta -chain, glutamic acid replaced by valine. During conditions of oxygen deficiency 6- valine forms hydrophobic bonds with complementary sites of other globin molecules. It distorts their configuration. As a result, erythrocytes having haemoglobin -S become sickle shaped and thus they are protected against malaria because of their particular haemoglobin mutation.
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How does sickle cell anemia provide immunity against malaria among African population ?
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