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Name the ion responsible for unmasking of active sites for myosin for cross-bridge activity during muscle contraction.
  • a)
    Calcium
  • b)
    Magnesium
  • c)
    Sodium
  • d)
    Potassium
Correct answer is option 'A'. Can you explain this answer?
Most Upvoted Answer
Name the ion responsible for unmasking of active sites for myosin for ...
Calcium ion as the unmasking agent for myosin active sites
There are several ions involved in muscle contraction, but one of the key ions responsible for unmasking the active sites on myosin for cross-bridge activity is calcium.
  • Role of calcium: Calcium ions play a vital role in the process of muscle contraction. When a muscle is stimulated to contract, calcium ions are released from the sarcoplasmic reticulum into the cytoplasm of the muscle cell.
  • Binding to troponin: The released calcium ions bind to the regulatory protein troponin, causing a conformational change in the protein complex troponin-tropomyosin, which covers the active sites on actin molecules.
  • Unmasking of active sites: This conformational change induced by calcium binding allows the active sites on actin to be exposed, enabling the myosin heads to bind to actin and form cross-bridges.
  • Cross-bridge formation: Once the myosin heads bind to the exposed active sites on actin, the cross-bridge cycle can proceed, leading to muscle contraction.
  • Regulation of contraction: The level of intracellular calcium ions is tightly regulated in muscle cells to ensure precise control over muscle contraction and relaxation.


In conclusion, calcium ions are essential for unmasking the active sites on myosin during muscle contraction, allowing for the formation of cross-bridges between actin and myosin filaments.
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Community Answer
Name the ion responsible for unmasking of active sites for myosin for ...
Calcium ions bind with TpC unit of troponin which is responsible for unmasking of active sites for myosin for cross-bridge activity during muscles contraction.
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Name the ion responsible for unmasking of active sites for myosin for cross-bridge activity during muscle contraction.a)Calciumb)Magnesiumc)Sodiumd)PotassiumCorrect answer is option 'A'. Can you explain this answer?
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