Deoxyhaemoglobin binds with more H thanoxyhaemoglobin does. It is des...
In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of residues that form temporary bonds with the substrate (binding site) and residues that catalyse a reaction of that substrate (catalytic site).
Deoxyhaemoglobin binds with more H thanoxyhaemoglobin does. It is des...
Haldane's Effect:
The Haldane effect is a phenomenon where the binding of oxygen to haemoglobin causes a conformational change that alters the affinity of the haemoglobin molecule for carbon dioxide.
Explanation:
Deoxyhaemoglobin (haemoglobin without oxygen) has a greater affinity for carbon dioxide than oxyhaemoglobin (haemoglobin with oxygen). When blood is in the lungs and oxygen is abundant, haemoglobin readily binds with oxygen to form oxyhaemoglobin. This causes a decrease in the affinity of haemoglobin for carbon dioxide and more carbon dioxide is released from the blood into the lungs to be exhaled. In contrast, when blood is in the tissues where oxygen is low, haemoglobin releases oxygen to the tissues. As a result, the affinity of haemoglobin for carbon dioxide increases, and more carbon dioxide binds to haemoglobin to be carried back to the lungs for exhalation.
Therefore, deoxyhaemoglobin binds with more carbon dioxide than oxyhaemoglobin does. This phenomenon is known as the Haldane effect.
Conclusion:
The Haldane effect is an important mechanism that allows the body to efficiently transport both oxygen and carbon dioxide in the blood. It ensures that carbon dioxide is efficiently transported from the tissues to the lungs for exhalation and that oxygen is efficiently transported from the lungs to the tissues where it is needed for cellular respiration.
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