Thalassemia and sickle cell anemia are caused dueto a problem in globin molecule synthesis. Selectthe correct statement :a)Both are due to a quantitative defect in globinchain synthesisb)Thalassemia is due to less synthesis of globinmoleculesc)Sickel cell anemia is due to a quantitativeproblem of globin moleculesd)Both are due to a qualitative defect in globinchain synthesisCorrect answer is option 'B'. Can you explain this answer?

Question

Answer

Thalassemia is due to.less synthesis of globin molecule hence quantity formed of globin molecule is less so it is quantitative while sickle cell anemia is due to.substitution of valine by glutamic acid hence it affects quality of globi chain that's why it is qualitative disorder

Answer

Thalassemia is a quantitative defect whereas sickle cell anaemia is a qualitative defect.Becaause sickel cell anaemia is caused by the substitution of Glu by val at the 6th position of beta globin chain,whereas Thalassemia is due to the reduced rate of synthesis of any pf the globin chains.Hence correct option is B

Answer

Sickel cell anaemia is due to substitution of base pair  whereas in thalassemia synthesis of globin chain is affected

Answer

While thalessemia is caused by a defect in the
globin gene, controlling the production of the globin chains of hemoglobin, sickle cell disease is caused by a defect in hemoglobin itself with the presence of abnormal hemoglobin S. Thalessemia is quantitative defect and sickle cell anaemia is qualitative defect . hence,the correct ans is op B.

Answer

Explanation:

Thalassemia:
Thalassemia is a genetic disorder characterized by a reduced synthesis of globin chains, which are essential components of hemoglobin. Hemoglobin is responsible for carrying oxygen in the red blood cells. Thalassemia occurs due to mutations in the genes that code for the globin chains, leading to decreased production of one or more types of globin chains.

Sickle Cell Anemia:
Sickle cell anemia is also a genetic disorder caused by a mutation in the gene that codes for the beta globin chain of hemoglobin. This mutation leads to the production of abnormal hemoglobin known as hemoglobin S. Hemoglobin S causes the red blood cells to become sickle-shaped, stiff, and prone to breakdown. This results in a decreased ability of the red blood cells to carry oxygen and can cause blockages in the blood vessels, leading to various complications.

Difference between Thalassemia and Sickle Cell Anemia:

Quantitative Defect:
- Thalassemia: Thalassemia is characterized by a quantitative defect in globin chain synthesis. It results in a decreased production of one or more types of globin chains.
- Sickle Cell Anemia: Sickle cell anemia is not primarily a quantitative defect but rather a qualitative defect. It involves the production of abnormal hemoglobin S instead of normal hemoglobin A.

Qualitative Defect:
- Thalassemia: Thalassemia is not primarily a qualitative defect. The problem lies in the reduced synthesis of globin chains.
- Sickle Cell Anemia: Sickle cell anemia is primarily a qualitative defect as it involves the production of abnormal hemoglobin S, which leads to the characteristic sickling of red blood cells.

Correct Statement:
The correct statement is option B, which states that thalassemia is due to less synthesis of globin molecules. Thalassemia is characterized by a quantitative defect in globin chain synthesis, resulting in a decreased production of one or more types of globin chains. Sickle cell anemia, on the other hand, is primarily a qualitative defect caused by the production of abnormal hemoglobin S.

Answer

Thalassemia is due less synthesis of beta chain of hamoglobin while sickle cell anemia is due mutation in the beta hamoglobin i.e it code for valine in place of glutamic acid ..

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