Read the following and answer any four questions from 5(i) to 5(v) gi...
The two subunits o f ribosomes come together at the time of protein formation. This phenomenon is called association. Mg2+ is essential for it.
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Read the following and answer any four questions from 5(i) to 5(v) gi...
Essential Ion for Association of Ribosome Units
Introduction:
During the process of translation, amino acids are polymerized to form a polypeptide chain. The sequence of amino acids is determined by the sequence of bases in the mRNA. The ribosome is the cellular machinery responsible for protein synthesis. It consists of two subunits, the large and small subunits, which come together during protein formation. The association of these ribosome units requires the presence of a specific ion.
The Role of Magnesium Ion:
The essential ion for the association of both units of the ribosome at the time of protein formation is Mg2+ (Magnesium ion).
Importance of Magnesium Ion:
1. Stabilization of Ribosome Structure: Magnesium ions play a crucial role in stabilizing the structure of ribosomes. They interact with the ribosomal RNA (rRNA) and proteins present in the ribosome, facilitating the proper folding and assembly of the ribosome units.
2. Peptide Bond Formation: During translation, the ribosome catalyzes the formation of peptide bonds between amino acids, resulting in the synthesis of a polypeptide chain. Magnesium ions act as cofactors for the peptidyl transferase activity of the ribosome, promoting the formation of peptide bonds between adjacent amino acids.
3. Ribosome Association: The large and small subunits of the ribosome associate with each other to form the functional ribosome complex. Magnesium ions facilitate this association by interacting with specific regions of the ribosome, promoting the binding of the subunits and ensuring their proper alignment for protein synthesis.
4. Stability of tRNA Binding: Transfer RNA (tRNA) molecules play a crucial role in delivering amino acids to the ribosome during translation. Magnesium ions stabilize the binding of tRNA to the ribosome, enhancing the accuracy and efficiency of protein synthesis.
Conclusion:
In summary, the association of both units of the ribosome during protein formation requires the presence of magnesium ions. These ions stabilize the ribosome structure, promote peptide bond formation, facilitate ribosome association, and enhance the stability of tRNA binding. Mg2+ is therefore an essential ion for efficient and accurate protein synthesis.
Read the following and answer any four questions from 5(i) to 5(v) gi...
Divalent metal ions serve an essential role in processes such as DNA bending and folding of RNA . In particular, magnesium ions play an important role in the subunits association, tRNA binding to the decoding site, and in general the structure and the stability of the ribosome
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