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If both parents are carriers for thalassaemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?
- a)25%
- b)100%
- c)No chance
- d)50%
Correct answer is option 'A'. Can you explain this answer?
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Verified Answer
If both parents are carriers for thalassaemia, which is an autosomal r...
Thalassemia-autosomal-linked recessive
AA-Normal
Aa-Carrier
aa-Disease
Affected = 1/4 = 25%
An autosomal recessive disorder like thalassemia is caused by abnormalities in both members of a pair of genes. Both parents may carry a single dose of the gene on one chromosome but have a normal gene on the other chromosome, which prevents the appearance of the disease in the carrier parent. A child must get one abnormal gene from each parent in order to be affected by the disease. Parents who are both carriers of an autosomal recessive disorder have a 25% risk of producing an offspring affected by the disease and a 50% risk of producing normal-appearing carriers.
AA-Normal
Aa-Carrier
aa-Disease
Affected = 1/4 = 25%
An autosomal recessive disorder like thalassemia is caused by abnormalities in both members of a pair of genes. Both parents may carry a single dose of the gene on one chromosome but have a normal gene on the other chromosome, which prevents the appearance of the disease in the carrier parent. A child must get one abnormal gene from each parent in order to be affected by the disease. Parents who are both carriers of an autosomal recessive disorder have a 25% risk of producing an offspring affected by the disease and a 50% risk of producing normal-appearing carriers.
Most Upvoted Answer
If both parents are carriers for thalassaemia, which is an autosomal r...
Thalassaemia is an autosomal recessive disorder, which means that an individual must inherit two copies of the defective gene (one from each parent) to develop the disease.
Possible genotypes of the parents:
- Homozygous normal (AA)
- Heterozygous carrier (Aa)
- Homozygous affected (aa)
Possible genotypes of the offspring:
- Homozygous normal (AA)
- Heterozygous carrier (Aa)
- Homozygous affected (aa)
Using a Punnett square, we can determine the probability of each genotype in the offspring:
| | A | a |
|---|---|---|
| A | AA | Aa |
| a | Aa | aa |
- 25% chance of homozygous normal (AA)
- 50% chance of heterozygous carrier (Aa)
- 25% chance of homozygous affected (aa)
Therefore, if both parents are carriers for thalassaemia, there is a 25% chance that a pregnancy will result in an affected child.
Possible genotypes of the parents:
- Homozygous normal (AA)
- Heterozygous carrier (Aa)
- Homozygous affected (aa)
Possible genotypes of the offspring:
- Homozygous normal (AA)
- Heterozygous carrier (Aa)
- Homozygous affected (aa)
Using a Punnett square, we can determine the probability of each genotype in the offspring:
| | A | a |
|---|---|---|
| A | AA | Aa |
| a | Aa | aa |
- 25% chance of homozygous normal (AA)
- 50% chance of heterozygous carrier (Aa)
- 25% chance of homozygous affected (aa)
Therefore, if both parents are carriers for thalassaemia, there is a 25% chance that a pregnancy will result in an affected child.
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If both parents are carriers for thalassaemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?a)25%b)100%c)No chanced)50%Correct answer is option 'A'. Can you explain this answer?
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